3-bromo-5-nitro-1H-indole

Product Name: 3-bromo-5-nitro-1H-indole
CAS No.: 525593-33-3
Chemical Name: 3-bromo-5-nitro-1H-indole
Synonyms: 3-Bromo-5-nitroindole;3-bromo-5-nitro-1H-indole;1H-Indole, 3-bromo-5-nitro-
CBNumber: CB41509359
Molecular Formula: C8H5BrN2O2
Formula Weight: 241.04
MOL File: 525593-33-3.mol

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3-bromo-5-nitro-1H-indole Property

Melting point:: 191-194 °C
Boiling point:: 417.6±25.0 °C(Predicted)
Density: 1.855
storage temp.: 2-8°C
pka: 13.58±0.30(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B697995
Product name: 3-Bromo-5-nitro-1h-indole
Packaging: 1g
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152557
Product name: 3-Bromo-5-nitro-1H-indole
Packaging: 2mg
Price: $59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152557
Product name: 3-Bromo-5-nitro-1H-indole
Packaging: 10mg
Price: $203
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB152557
Product name: 3-Bromo-5-nitro-1H-indole
Packaging: 25mg
Price: $405
Updated: 2021/12/16

AK Scientific

Product number: V6390
Product name: 3-Bromo-5-nitro-1h-indole
Packaging: 10g
Price: $498
Updated: 2021/12/16

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3-bromo-5-nitro-1H-indole Chemical Properties,Usage,Production

Synthesis

6146-52-7

525593-33-3

Step A: A solution of pyridinium bromide (10.99 g, 34.3 mmol) in pyridine (200 mL) was slowly added dropwise to a solution of pyridinium bromide (10.99 g, 34.3 mmol) in pyridine (200 mL) of 5-nitroindole (5.00 g, 30.8 mmol) at -40 °C and under nitrogen protection. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 5 minutes. Subsequently, the reaction mixture was diluted with water (200 mL) at 0 °C and extracted with ether (200 mL). The organic layer was washed sequentially with 6 M hydrochloric acid (300 mL), 5% sodium bicarbonate solution (300 mL) and saturated saline (300 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give 3-bromo-5-nitroindole as a yellow powder with 80% purity containing 20% 5-nitroindole (6.80 g, 74% yield).

References

[1] Tetrahedron Letters, 2003, vol. 44, # 20, p. 3927 - 3930
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 17, p. 5965 - 5980
[3] RSC Advances, 2016, vol. 6, # 93, p. 90031 - 90034
[4] Tetrahedron Letters, 2015, vol. 56, # 9, p. 1096 - 1098
[5] Patent: WO2006/19831, 2006, A1. Location in patent: Page/Page column 415

3-bromo-5-nitro-1H-indole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-bromo-5-nitro-1H-indole Suppliers

Canada 1 China 79 India 2 Ukraine 2 United Kingdom 1 United States 10 Global 95

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525593-33-3