ChemicalBook > CAS DataBase List > H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH

Product Name
H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
CAS No.
188859-65-6
Chemical Name
H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
Synonyms
HSLGKLLGRPDKF;L144, R147-PLP(139-151);[LEU144, ARG147]-PLP (139-151);6:PN:WO0053019 SEQID:6 claimed sequence;HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE;(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151);H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH;[Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)];L-Phenylalanine, L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-
CBNumber
CB4153896
Molecular Formula
C67H110N20O17
Formula Weight
1467.71
MOL File
Mol file
More
Less

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
-15°C
pka
3.49±0.10(Predicted)
Sequence
His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
LIP0001016
Product name
(LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151)
Purity
95.00%
Packaging
5MG
Price
$505.46
Updated
2021/12/16
More
Less

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Chemical Properties,Usage,Production

Uses

[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE)[1].

References

[1] Nicholson LB, et al. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9279-84. DOI:10.1073/pnas.94.17.9279

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH Suppliers

China 37 The Netherlands 1 United Kingdom 1 United States 4 Global 43
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30

188859-65-6, H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OHRelated Search:

PLP (139-151)

  • [Leu144, Arg147] - PLP (139 - 151), [L144, R147 - PLP(139 - 151)]
  • SER-HIS-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE
  • (LEU144,ARG147)-MYELIN PROTEOLIPID PROTEIN (139-151)
  • [LEU144, ARG147]-PLP (139-151)
  • L144, R147-PLP(139-151)
  • H-HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE-OH
  • HIS-SER-LEU-GLY-LYS-LEU-LEU-GLY-ARG-PRO-ASP-LYS-PHE
  • HSLGKLLGRPDKF
  • 6:PN:WO0053019 SEQID:6 claimed sequence
  • L-Phenylalanine, L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-
  • 188859-65-6
  • C67H110N20O17
  • peptide