ChemicalBook > CAS DataBase List > (2-Trifluoromethyl-pyridin-4-yl)-methanol

(2-Trifluoromethyl-pyridin-4-yl)-methanol

Product Name
(2-Trifluoromethyl-pyridin-4-yl)-methanol
CAS No.
131747-61-0
Chemical Name
(2-Trifluoromethyl-pyridin-4-yl)-methanol
Synonyms
2-(TrifluoroMethyl)-4-pyridineMethanol;2-(Trifluoromethyl)pyridine-4-methanol;[2-(trifluoromethyl)-4-pyridyl]methanol;4-PyridineMethanol, 2-(trifluoroMethyl)-;(2-Trifluoromethyl-pyridin-4-yl)-methanol;4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine;4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine 95%;[2-(Trifluoromethyl)pyridin-4-yl]methanol, 2-(Trifluoromethyl)isonicotinyl alcohol
CBNumber
CB41553842
Molecular Formula
C7H6F3NO
Formula Weight
177.12
MOL File
131747-61-0.mol
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(2-Trifluoromethyl-pyridin-4-yl)-methanol Property

Boiling point:
212.6±35.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
13.13±0.10(Predicted)
form 
liquid
color 
Colourless
InChI
InChI=1S/C7H6F3NO/c8-7(9,10)6-3-5(4-12)1-2-11-6/h1-3,12H,4H2
InChIKey
UOQWDROTEICSEX-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=CC(CO)=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC49314
Product name
4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
500mg
Price
$221
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-3-W5
Product name
4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
Packaging
500mg
Price
$244
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
T14095
Product name
[2-(Trifluoromethyl)pyridin-4-yl]methanol
Packaging
1g
Price
$300
Updated
2021/12/16
Apolloscientific
Product number
PC49314
Product name
4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
Purity
95%
Packaging
250mg
Price
$122
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-3-W5
Product name
4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
Packaging
250mg
Price
$135
Updated
2021/12/16
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(2-Trifluoromethyl-pyridin-4-yl)-methanol Chemical Properties,Usage,Production

Synthesis

131747-41-6

131747-61-0

General procedure for the synthesis of (2-trifluoromethyl-pyridin-4-yl)-methanol from 2-(trifluoromethyl)isonicotinic acid: 2-(trifluoromethyl)isonicotinic acid (10.0 g, 52.4 mmol) was dissolved in tetrahydrofuran (150 mL) and cooled down to 0 °C. Under nitrogen protection, 1 mol/L borane-tetrahydrofuran solution (105 mL, 105 mmol) was slowly added. The reaction mixture was heated to 75 °C and the reaction was stirred for 2 hours. After completion of the reaction, the mixture was carefully poured into ice water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford the target product (2-trifluoromethyl-pyridin-4-yl)-methanol (5.60 g, 31.6 mmol, 60% yield). Mass spectrum (ESI) m/z: 178 ([M+H]+). 1H NMR (300 MHz, CDCl3): δ 8.68 (d, J=4.8Hz, 1H), 7.79 (s, 1H), 7.64 (d, J=4.8Hz, 1H), 5.62 (br-s, 1H), 4.66 (s, 2H).

References

[1] Patent: US2016/332999, 2016, A1. Location in patent: Paragraph 0775; 0776; 0777; 0778
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: WO2015/138220, 2015, A1. Location in patent: Page/Page column 69
[4] Patent: WO2016/29454, 2016, A1. Location in patent: Page/Page column 59

(2-Trifluoromethyl-pyridin-4-yl)-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (2-Trifluoromethyl-pyridin-4-yl)-methanol manufacturers

Career Henan Chemical Co
Product
(2-Trifluoromethyl-pyridin-4-yl)-methanol 131747-61-0
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

131747-61-0, (2-Trifluoromethyl-pyridin-4-yl)-methanolRelated Search:

(6-CHLORO-2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-YL)(PIPERIDIN-2-YL)METHANOL 5-BROMO-2-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXYLIC ACID CARBOXYMEFLOQUINE 2-(Trifluoromethyl)isonicotinic acid 3-FLUORO-2-TRIFLUOROMETHYL-ISONICOTINIC ACID 2-[2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLYL]OXIRANE ENPIROLINE alpha-2-pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol (2,8-BIS-TRIFLUOROMETHYL-QUINOLIN-4-YL)-PIPERIDIN-2-YL-METHANOL HYDROCHLORIDE(R*,R*) 2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 97 Mefloquine hydrochloride

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