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Mefloquine hydrochloride

Product Name
Mefloquine hydrochloride
CAS No.
51773-92-3
Chemical Name
Mefloquine hydrochloride
Synonyms
Loriam;wr14249;wr142490;MEFLOQUINE HCL;Ro 21-5998/001;s*)-(r(+-)-lorid;Mefloquin hydrochloride;efloquine hydrochloride;MEFLOQUINE HYDROCHLORIDE;MefloquineHydrochloride>
CBNumber
CB6252498
Molecular Formula
C17H17ClF6N2O
Formula Weight
414.77
MOL File
51773-92-3.mol
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Mefloquine hydrochloride Property

Melting point:
250-254?C
storage temp. 
2-8°C
solubility 
DMSO: 38 mg/mL, soluble
form 
solid
color 
white
λmax
222nm(Acidic H2O)(lit.)
Merck 
14,5801
BCS Class
4/2
Stability:
Temperature Sensitive
InChI
InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
InChIKey
WESWYMRNZNDGBX-YLCXCWDSSA-N
SMILES
C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
CAS DataBase Reference
51773-92-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
VC0308000
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2319
Product name
Mefloquine hydrochloride
Purity
≥98% (HPLC), powder
Packaging
100mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1379059
Product name
Mefloquine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$393
Updated
2024/03/01
TCI Chemical
Product number
M2313
Product name
Mefloquine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
1g
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
23665
Product name
Mefloquine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
23665
Product name
Mefloquine (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$87
Updated
2024/03/01
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Mefloquine hydrochloride Chemical Properties,Usage,Production

Description

Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.

Description

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties. It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites. It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis. Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior. Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.

Chemical Properties

White Solid

Originator

Walter Reed (USA)

Uses

Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.

Uses

Antimalarial;Heme polymerase inhibitor

Definition

ChEBI: Mefloquine hydrochloride is a hydrochloride.

brand name

FANSIMEF

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Biochem/physiol Actions

Blocker of gap junction channels Cx36 and Cx50.

Clinical Use

The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.

storage

Store at +4°C

Mefloquine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mefloquine hydrochloride Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 4 China 163 Europe 4 France 2 Germany 2 India 19 Japan 2 Poland 1 Spain 2 Switzerland 3 United Kingdom 11 United States 34 Global 250
Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
193
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
Advantage
62
Wuhan Wei Shunda Technology Development Co., Ltd.
Tel
86-027-88774375
Fax
86-027-88416321
Email
mwmwhot@163.com
Country
China
ProdList
233
Advantage
65
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Zhemical Co., Ltd.
Tel
0760-89935616
Fax
+86 (760) 8533-0775
Email
zc@zhemical.com
Country
China
ProdList
172
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
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View Lastest Price from Mefloquine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mefloquine hydrochloride 51773-92-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10kg/month
Release date
2021-12-27
Baoji Guokang Healthchem co.,ltd
Product
Mefloquine hydrochloride 51773-92-3
Price
US $1428.60-317.50/g
Min. Order
40g
Purity
99%
Supply Ability
200kg
Release date
2021-06-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
mefloquine hydrochloride 51773-92-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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  • Mefloquine Hydrochloride (1379059)
  • 51773-92-3
  • C17H16F6N2OHCl
  • C17H16F6N2OClH
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