ChemicalBook > CAS DataBase List > 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

Product Name
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
CAS No.
85547-56-4
Chemical Name
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
Synonyms
Pipraquine Phosphate;PIPERAQUINE PHOSPHATE;Pipertaquine phosphate;antimalarial drugs PIPERAQUINE PHOSPHATE;2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline);4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP;Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate
CBNumber
CB02131090
Molecular Formula
C29H32Cl2N6.H3PO4
Formula Weight
633.51
MOL File
85547-56-4.mol
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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Property

storage temp. 
Store at -20°C
solubility 
DMSO: Insoluble;
form 
Solid
color 
Off-white to light yellow
Water Solubility 
Water: 2 mg/mL (3.16 mM)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
8213AH
Product name
Piperaquinetetraphosphate
Packaging
5mg
Price
$48
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134838
Product name
Piperaquine Phosphate
Purity
>99%
Packaging
100mg
Price
$510
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134838
Product name
Piperaquine Phosphate
Purity
>99%
Packaging
250mg
Price
$912.9
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003862
Product name
PIPERAQUINE PHOSPHATE
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
Biorbyt Ltd
Product number
orb134838
Product name
Piperaquine Phosphate
Purity
>99%
Packaging
1g
Price
$1504.5
Updated
2021/12/16
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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Chemical Properties,Usage,Production

Uses

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

in vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg?h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg?h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage:0, 10, 30, 90 mg/kg
Administration:A single i.p. administration
Result:The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model:Male Swiss mice (6 weeks old)[1]
Dosage:90 mg/kg (Pharmacokinetic Analysis)
Administration:A single i.p. administration
Result:t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

References

[1] Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. DOI:10.1128/AAC.00878-07
[2] Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. DOI:10.2165/00003495-200565010-00004

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Suppliers

China 67 India 8 United States 4 Global 79
Chongqing Kanglle Pharmaceutical Co., Ltd
Tel
023-62503614
Fax
023-62506103
Email
cqkl@cqkl.com.cn
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China
ProdList
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
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China
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225; 15527768850
Email
1791901229@qq.com
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China
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7001
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Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
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China
ProdList
3120
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Wuhan Dahua Pharmaceutical Co., Ltd.
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027-59262863 13277907145 3091977954
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027-59420980
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China
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4943
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Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
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027-59420981,18702770802
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027-83322098
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China
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1975
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50
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
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synchempharma@aliyun.com
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China
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6466
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
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60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
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Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1675
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58
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View Lastest Price from 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate manufacturers

Dideu Industries Group Limited
Product
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate 85547-56-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-17

85547-56-4, 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphateRelated Search:

Ammonium dihydrogen phosphate Benproperine phosphate Primaquine diphosphate Zinc phosphate Epichlorohydrin Clioquinol Resin epoxy Calcium phosphate FERRIC PHOSPHATE Sodium Phosphate Monobasic Monohydrate Creatine phosphate 1-Chloropropane Trisodium phosphate 1,1,1,2,3,3,3-HEPTACHLOROPROPANE Piperaquine phosphate triphosphate 7-CHLOROQUINOLINE

  • 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
  • PIPERAQUINE PHOSPHATE
  • Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate
  • antimalarial drugs PIPERAQUINE PHOSPHATE
  • 2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol
  • 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
  • 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP
  • Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate
  • Pipraquine Phosphate
  • Pipertaquine phosphate
  • 85547-56-4
  • C29H35Cl2N6O4P