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Mefloquine hydrochloride

Product Name
Mefloquine hydrochloride
CAS No.
51773-92-3
Chemical Name
Mefloquine hydrochloride
Synonyms
Loriam;wr14249;wr142490;MEFLOQUINE HCL;Ro 21-5998/001;s*)-(r(+-)-lorid;Mefloquin hydrochloride;efloquine hydrochloride;MEFLOQUINE HYDROCHLORIDE;MefloquineHydrochloride>
CBNumber
CB6252498
Molecular Formula
C17H17ClF6N2O
Formula Weight
414.77
MOL File
51773-92-3.mol
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Mefloquine hydrochloride Property

Melting point:
250-254?C
storage temp. 
2-8°C
solubility 
DMSO: 38 mg/mL, soluble
form 
solid
color 
white
λmax
222nm(Acidic H2O)(lit.)
Merck 
14,5801
BCS Class
4/2
Stability:
Temperature Sensitive
InChI
InChI=1/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/s3
InChIKey
WESWYMRNZNDGBX-YLCXCWDSSA-N
SMILES
C12N=C(C=C([C@@H](O)[C@@]3([H])NCCCC3)C=1C=CC=C2C(F)(F)F)C(F)(F)F.Cl |&1:5,7,r|
CAS DataBase Reference
51773-92-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
VC0308000
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2319
Product name
Mefloquine hydrochloride
Purity
≥98% (HPLC), powder
Packaging
100mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1379059
Product name
Mefloquine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$393
Updated
2024/03/01
TCI Chemical
Product number
M2313
Product name
Mefloquine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
1g
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
23665
Product name
Mefloquine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
23665
Product name
Mefloquine (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$87
Updated
2024/03/01
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Mefloquine hydrochloride Chemical Properties,Usage,Production

Description

Mefloquine hydrochloride is an erythrocytic schizonticide useful, in combination with sulfadoxine and pyrimethamine, in the prophylaxis and treatment of malaria. Administered once weekly, the combination is effective against pathogens resistant to other agents.

Description

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties. It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites. It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis. Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior. Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.

Chemical Properties

White Solid

Originator

Walter Reed (USA)

Uses

Mefloquine Hydrochloride (Polymorph Form E) is a polymorphic form of Mefloquine Hydrochloride (M207055), a quinoline methanol antimalarial agent.

Uses

Antimalarial;Heme polymerase inhibitor

Definition

ChEBI: Mefloquine hydrochloride is a hydrochloride.

brand name

FANSIMEF

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards

Biochem/physiol Actions

Blocker of gap junction channels Cx36 and Cx50.

Clinical Use

The newest of the 4-aminoquinolines,mefloquine, is marketed as the R,S-isomer. It was developedin the 1960s as part of the U.S. Army’s WalterReed Institute for Medical Research antimalarial researchprogram. It differs significantly from the other agents in this class by having two trifluromethyl moieties at positions2’ and 8' and no electronegative substituents at eitherpositions 6' (quinine) or 7' (chloroquine). Mefloquine alsodiffers from chloroquine and its analogs by being a schizonticide acting before the parasite canenter the erythrocyte. There is some evidence that it acts byraising the pH in the parasite’s vesicles interfering with itsability to process heme. Mefloquine-resistant strains ofP. falciparum have appeared. Relapse can occur with acuteP. vivax that has been treated with mefloquine because thedrug does not eliminate the hepatic phase of this species,which can reinfect the liver.
Mefloquine is teratogenic in rats, mice, and rabbits. Thereis an FDA-required warning that this drug can cause exacerbatemental disorders and is contraindicated in patients withactive depression, a recent history of depression, generalizedanxiety disorder, psychosis, schizophrenia, and other majorpsychiatric disorders or a history of convulsions.

storage

Store at +4°C

Mefloquine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mefloquine hydrochloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Mefloquine hydrochloride 51773-92-3
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mefloquine hydrochloride 51773-92-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10kg/month
Release date
2021-12-27
Baoji Guokang Healthchem co.,ltd
Product
Mefloquine hydrochloride 51773-92-3
Price
US $1428.60-317.50/g
Min. Order
40g
Purity
99%
Supply Ability
200kg
Release date
2021-06-07

51773-92-3, Mefloquine hydrochlorideRelated Search:

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  • C17H16F6N2OHCl
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