(6-methoxypyridin-3-yl)methanol
- Product Name
- (6-methoxypyridin-3-yl)methanol
- CAS No.
- 58584-63-7
- Chemical Name
- (6-methoxypyridin-3-yl)methanol
- Synonyms
- 6-Methoxy-3-PyridineMethanol;2-Methoxypyridine-5-Methanol;2-Methoxypyridine-5-metha...;2-Methoxy-5-pyridinemethanol;(6-Methoxy-3-pyridyl)methanol;3-Pyridinemethanol, 6-methoxy-;(6-methoxy-3-pyridinyl)methanol;(6-methoxypyridin-3-yl)methanol;1-(6-Methoxypyridin-3-yl)methanol;2-Methoxy-5-hydroxymethylpyridine
- CBNumber
- CB41554157
- Molecular Formula
- C7H9NO2
- Formula Weight
- 139.15
- MOL File
- 58584-63-7.mol
(6-methoxypyridin-3-yl)methanol Property
- Boiling point:
- 258℃
- Density
- 1.155
- Flash point:
- 110℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.42±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M336843
- Product name
- (6-Methoxypyridin-3-yl)methanol
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M336843
- Product name
- (6-Methoxypyridin-3-yl)methanol
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z4909
- Product name
- (6-Methoxypyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 4H56-1-QR
- Product name
- 2-Methoxypyridine-5-methanol
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 068836
- Product name
- (6-Methoxy-3-pyridyl)methanol
- Purity
- >95%
- Packaging
- 500mg
- Price
- $555
- Updated
- 2021/12/16
(6-methoxypyridin-3-yl)methanol Chemical Properties,Usage,Production
Synthesis
26218-80-4
58584-63-7
The general procedure for the synthesis of (6-methoxypyridin-3-yl)methanol from methyl 6-methoxynicotinate is as follows: Preparation Example 1: Synthesis of (6-methoxypyridin-3-yl)methanol (2) Methyl-6-methoxynicotinate (1) (650 g, 3.89 mol) was dissolved in tert-butyl methyl ether (MTBE, 6.5 L) and cooled in an ice bath under nitrogen protection. Sodium bis(2-methoxyethoxy) aluminum hydride (65% toluene solution, 1.45 kg, 4.67 mol) was slowly added to the reaction system over 1.5 hours. After addition, stirring was continued for 20 minutes. An aqueous 3.5N sodium hydroxide solution (2.6L) was slowly added while keeping the reaction temperature below 15°C. The reaction mixture was warmed up to 32°C and stirred for 45 minutes. After completion of the reaction, the organic layer was separated and the aqueous layer was extracted again with MTBE (2.3 L). The organic layers were combined and concentrated to dryness under reduced pressure. Toluene (1.3 L) was added to the residue and azeotropic distillation was performed. This azeotropic distillation process was repeated three times to give 597 g of the title compound as a light yellow oil (100% yield). 1H-NMR (CDCl3) δ (ppm): 8.11 (1H, d, J=2.4Hz), 7.62 (1H, dd, J=2.4Hz, 8.8Hz), 6.75 (1H, d, J=8.8Hz), 4.62 (2H, s), 3.93 (3H, s).
References
[1] Patent: US2006/235225, 2006, A1. Location in patent: Page/Page column 3
[2] Patent: WO2011/73845, 2011, A1. Location in patent: Page/Page column 123
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[4] Patent: WO2015/158427, 2015, A1. Location in patent: Page/Page column 132
[5] Tetrahedron, 1992, vol. 48, # 8, p. 1457 - 1464
(6-methoxypyridin-3-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
(6-methoxypyridin-3-yl)methanol Suppliers
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 13761627472
- Fax
- 86-21-64965863
- 183009664@qq.com
- Country
- China
- ProdList
- 649
- Advantage
- 62
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
View Lastest Price from (6-methoxypyridin-3-yl)methanol manufacturers
- Product
- (6-Methoxypyridin-3-yl)methanol 58584-63-7
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-14
- Product
- (6-methoxypyridin-3-yl)methanol 58584-63-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-18