5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Product Name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.: 866028-06-0
Chemical Name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
Synonyms: -Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4’1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine;1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate;tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat;tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018];tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate;5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester
CBNumber: CB41559990
Molecular Formula: C17H21FN2O3
Formula Weight: 320.36
MOL File: 866028-06-0.mol

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5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 473.6±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.54±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B601195
Product name: 1''-Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4''-piperidine]
Packaging: 50mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: W8892
Product name: 1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
Packaging: 250mg
Price: $253
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044664
Product name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $496.3
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35098
Product name: tert-Butyl5-fluoro-2-oxospiro[indoline-3,4?-piperidine]-1?-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $515
Updated: 2021/12/16

AK Scientific

Product number: W8892
Product name: 1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
Packaging: 1g
Price: $558
Updated: 2021/12/16

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5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

56341-41-4

118753-70-1

866028-06-0

General procedure for the synthesis of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] from 5-fluoroindol-2-one and tert-butyl N,N-bis(2-chloroethyl)carbamate: to a stirred solution of 5-fluoroindol-2-one (1.80 g, 11.9 mmol) in tetrahydrofuran (30 mL) at -78 °C A tetrahydrofuran solution (35.7 mL, 35.7 mmol) of 1 M sodium bis(trimethylmethylsilyl)amide was slowly added dropwise for 15 min. The reaction mixture was continued to be stirred at the same temperature for 1.5 hours. Subsequently, tert-butyl N,N-bis(2-chloroethyl)carbamate (2.88 g, 11.9 mmol) solution of tetrahydrofuran (10 mL) was added dropwise to the reaction mixture at -78 °C. After dropwise addition, the reaction mixture was slowly warmed to room temperature and stirred at that temperature for 19 hours. Upon completion of the reaction, the reaction was quenched by the addition of an aqueous ammonium chloride solution and the reaction mixture was subsequently concentrated to give a brown residue. The crude product was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent evaporated. The residue was purified by column chromatography on silica gel (100 g) using hexane/acetone (3/1) as eluent, resulting in 356 mg (15% yield) of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] as a light brown slurry. The product was confirmed by 1H-NMR (CDCl3) and mass spectrometry (ESI): 1H-NMR (CDCl3) δ 8.56 (1H, br.s), 7.03-6.83 (3H, m), 3.89-3.69 (4H, m), 1.92-1.72 (4H, m), 1.50 (9H, s); MS (ESI) 319 (M-H)- .

References

[1] Patent: WO2005/92858, 2005, A2. Location in patent: Page/Page column 60
[2] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 40

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

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Pure Chemistry Scientific Inc.

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Biokitchen

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View Lastest Price from 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 866028-06-0
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

866028-06-0, 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:

1-N-BOC-4-AMINOMETHYL-4-PHENYLPIPERIDINE [2-(2,3-DIHYDRO-1H-INDOL-3-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER SPIRO[INDOLINE-3,4'-PIPERIDINE] PIPERIDINE-4-CARBOXYLIC ACID (4-FLUORO-PHENYL)-AMIDE 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE 1'-N-BOC-1,2-DIHYDRO-1'H-SPIRO[INDOLE-3,4'-PIPERIDINE] 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]

tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate

tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate

tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester

-Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4&rsquo

1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine

tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018]

866028-06-0

C17H21FN2O3