5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Product Name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
CAS No.: 866028-06-0
Chemical Name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
Synonyms: -Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4’1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine;1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine];tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate;tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate;tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat;tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018];tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate;5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester
CBNumber: CB41559990
Molecular Formula: C17H21FN2O3
Formula Weight: 320.36
MOL File: 866028-06-0.mol

More

Less

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 473.6±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.54±0.20(Predicted)
Appearance: White to off-white Solid

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B601195
Product name: 1''-Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4''-piperidine]
Packaging: 50mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: W8892
Product name: 1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
Packaging: 250mg
Price: $253
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044664
Product name: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $496.3
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35098
Product name: tert-Butyl5-fluoro-2-oxospiro[indoline-3,4?-piperidine]-1?-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $515
Updated: 2021/12/16

AK Scientific

Product number: W8892
Product name: 1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
Packaging: 1g
Price: $558
Updated: 2021/12/16

More

Less

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

56341-41-4

118753-70-1

866028-06-0

General procedure for the synthesis of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] from 5-fluoroindol-2-one and tert-butyl N,N-bis(2-chloroethyl)carbamate: to a stirred solution of 5-fluoroindol-2-one (1.80 g, 11.9 mmol) in tetrahydrofuran (30 mL) at -78 °C A tetrahydrofuran solution (35.7 mL, 35.7 mmol) of 1 M sodium bis(trimethylmethylsilyl)amide was slowly added dropwise for 15 min. The reaction mixture was continued to be stirred at the same temperature for 1.5 hours. Subsequently, tert-butyl N,N-bis(2-chloroethyl)carbamate (2.88 g, 11.9 mmol) solution of tetrahydrofuran (10 mL) was added dropwise to the reaction mixture at -78 °C. After dropwise addition, the reaction mixture was slowly warmed to room temperature and stirred at that temperature for 19 hours. Upon completion of the reaction, the reaction was quenched by the addition of an aqueous ammonium chloride solution and the reaction mixture was subsequently concentrated to give a brown residue. The crude product was partitioned between ethyl acetate and water and the organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent evaporated. The residue was purified by column chromatography on silica gel (100 g) using hexane/acetone (3/1) as eluent, resulting in 356 mg (15% yield) of 1'-BOC-5-fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] as a light brown slurry. The product was confirmed by 1H-NMR (CDCl3) and mass spectrometry (ESI): 1H-NMR (CDCl3) δ 8.56 (1H, br.s), 7.03-6.83 (3H, m), 3.89-3.69 (4H, m), 1.92-1.72 (4H, m), 1.50 (9H, s); MS (ESI) 319 (M-H)- .

References

[1] Patent: WO2005/92858, 2005, A2. Location in patent: Page/Page column 60
[2] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 40

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers

China 36 India 1 United States 5 Global 42

Shanghai yirong biology science and technology co., ltd

Tel: 18049974220
Fax: +86 (21) 51062076
Email: 3060526242@qq.com
Country: China
ProdList: 995
Advantage: 60

Shanghai AQBioPharma Co., Ltd.

Tel: 13661411401
Fax: 51370935-8011
Email: yinglv.que@aqbiopharma.com.cn
Country: China
ProdList: 2930
Advantage: 58

ShangHai Wisacheam Pharmaceutical Co., Ltd.

Tel: 13817485796
Fax: QQ:895624079
Email: tim@wisacheampharm.com
Country: China
ProdList: 3592
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Civic Chemical Technology Co., Ltd.

Tel: 021-34053660
Fax: QQ:2881074831
Email: sale2@labgogo.com
Country: China
ProdList: 2018
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Sichuan BaiPeng Biotechnology Co., Ltd.

Tel: 028-65791793 18140026355
Fax: QQ568470422
Email: 568470422@qq.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Yinlin Pharmaceutical Co., Ltd.

Tel: 021-33690831
Fax: 021-33690831
Email: 813300142@qq.com
Country: China
ProdList: 305
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Block Chemical Technology (Shanghai) Co., LTD

Tel: 021-20432219 13918097649
Fax: QQ79021576
Email: li_jinfei@acblock-lab.com
Country: China
ProdList: 9673
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shanghai Hanlin biology science and technology co., ltd

Tel: 183-0212-4410 18302124410
Email: Djt18302124410@163.com
Country: China
ProdList: 3000
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Suzhou Meishi Biotechnology Co., Ltd.

Tel: 1173954148q
Email: meishipharma@126.com
Country: China
ProdList: 20033
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Shaanxi PharmaGHS Science Co., LTD

Tel: 13279368192
Email: pharmaghs@126.com
Country: China
ProdList: 2935
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: sales@pharmablock.com
Country: China
ProdList: 7268
Advantage: 58

Shanghai AQ BioPharma Co., Ltd.

Tel: 13512160998
Email: sales@aqbiopharma.com.cn
Country: China
ProdList: 2961
Advantage: 58

Sichuan Boyou Biotechnology Co., Ltd

Tel: 028-65791793 18140026355
Email: 568470422@qq.com
Country: China
ProdList: 9459
Advantage: 58

Qingdao Dexin Chemical Co., Ltd

Tel: +86-15553333686
Email: 15553333686@qq.com
Country: China
ProdList: 3113
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

More

Less

View Lastest Price from 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER manufacturers

Career Henan Chemical Co

Product: 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 866028-06-0
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

866028-06-0, 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:

1-N-BOC-4-AMINOMETHYL-4-PHENYLPIPERIDINE [2-(2,3-DIHYDRO-1H-INDOL-3-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER 1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER SPIRO[INDOLINE-3,4'-PIPERIDINE] PIPERIDINE-4-CARBOXYLIC ACID (4-FLUORO-PHENYL)-AMIDE 4-(2-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-[(4-FLUORO-PHENYLAMINO)-METHYL]-PIPERIDINE 1'-N-BOC-1,2-DIHYDRO-1'H-SPIRO[INDOLE-3,4'-PIPERIDINE] 5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

1'-Boc-5-Fluoro-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]

tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylat

5-FLUORO-1,2-DIHYDRO-2-OXO-SPIRO[3H-INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

tert-butyl 5-fluoro-2-oxospiro[1H-indole-3,4'-piperidine]-1'-carboxylate

tert-butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate

tert-Butyl 5-fluoro-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate

Spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid, 5-fluoro-1,2-dihydro-2-oxo-, 1,1-dimethylethyl ester

-Boc-5-fluoro-1,2-dihydro-2-oxo-spiro[3h-indole-3,4&rsquo

1'-Boc-5-Fluoro-1，2-dihydro-2-oxo-spiro[3H-indole-3，4'-piperidine

tert-Butyl 5-fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate - [B1018]

866028-06-0

C17H21FN2O3