ChemicalBook > CAS DataBase List > Ataciguat

Ataciguat

Product Name: Ataciguat
CAS No.: 254877-67-3
Chemical Name: Ataciguat
Synonyms: HMR 1766;HMR-1766A;Ataciguat;Ataciguat (HMR-1766;Ataciguat, 10 mM in DMSO;5-Chloro-2-(5-chlorothiophene-2-sulfonamido)-N-(4-(morpholinosulfonyl)phenyl)benzamide;5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide;Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-;cyclase,soluble,HMR 1766,Ataciguat,Guanylate Cyclase,Inhibitor,sGC,inhibit,HMR1766,vasodilator,cGMP,guanylate
CBNumber: CB41565384
Molecular Formula: C21H19Cl2N3O6S3
Formula Weight: 576.5
MOL File: 254877-67-3.mol

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Ataciguat Property

Density: 1.613±0.06 g/cm3(Predicted)
solubility: DMF: 1 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
form: A crystalline solid
pka: 5.70±0.50(Predicted)
color: White to off-white
InChIKey: PQHLRGARXNPFCF-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(S(N2CCOCC2)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1NS(C1SC(Cl)=CC=1)(=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2598
Product name: Ataciguat
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $101.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2598
Product name: Ataciguat
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $433
Updated: 2025/07/31

Cayman Chemical

Product number: 16371
Product name: Ataciguat
Purity: ≥95%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 16371
Product name: Ataciguat
Purity: ≥95%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 16371
Product name: Ataciguat
Purity: ≥95%
Packaging: 10mg
Price: $632
Updated: 2024/03/01

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Ataciguat Chemical Properties,Usage,Production

Uses

Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.

Ataciguat Preparation Products And Raw materials

Raw materials

Preparation Products

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Ataciguat Suppliers

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254877-67-3, AtaciguatRelated Search:

Ataciguat

5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide

Ataciguat

HMR 1766

Ataciguat (HMR-1766

Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-

cyclase,soluble,HMR 1766,Ataciguat,Guanylate Cyclase,Inhibitor,sGC,inhibit,HMR1766,vasodilator,cGMP,guanylate

5-Chloro-2-(5-chlorothiophene-2-sulfonamido)-N-(4-(morpholinosulfonyl)phenyl)benzamide

Ataciguat, 10 mM in DMSO

HMR-1766A

254877-67-3

C21H19Cl2N3O6S3

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds