TCY-NH2

Product Name: TCY-NH2
CAS No.: 327177-34-4
Chemical Name: TCY-NH2
Synonyms: TCY-NH2;M.W. 739.87 C40H49N7O7;trans-Cinnamoyl-YPGKF-NH2;TRANS-CINNAMOYL-YPGKF-AMIDE;trans-Cinnamoyl-YPGKF-NH2, tcY-NH2;TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2;Protease-Activated Receptor-4, PAR-4 Antagonist, amide - 1 mg;trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt;L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-
CBNumber: CB4157102
Molecular Formula: C40H49N7O7
Formula Weight: 739.86
MOL File: 327177-34-4.mol

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TCY-NH2 Property

storage temp.: −20°C
form: Powder
Water Solubility: Soluble to 1 mg/ml in water

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1488
Product name: tcY-NH2
Packaging: 1
Price: $219
Updated: 2021/12/16

TRC

Product number: N394025
Product name: tcY-NH2
Packaging: 1mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 256892
Product name: tcY-NH2
Packaging: 1mg
Price: $466
Updated: 2021/12/16

ApexBio Technology

Product number: B5123
Product name: tcY-NH2
Packaging: 1mg
Price: $322
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004622
Product name: TCY-NH2
Purity: 95.00%
Packaging: 5MG
Price: $495.5
Updated: 2021/12/16

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TCY-NH2 Chemical Properties,Usage,Production

Uses

tcY-NH2 does not cause aggregation but blocks aggregation caused by receptor-activating peptide analogs (GY-NH2, AY-NH2), and thrombin without affecting ADP-mediated aggregation.

in vivo

tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology^[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4⁺ Tregs within the draining lymph nodes in burn injury mice model ^[4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice^[6].

Animal Model:	Brain death (BD) rat model^[3]
Dosage:	0.6 mg/kg for a single dose
Administration:	Tail vein injection for a single dose
Result:	Reduced blood platelet activation and hepatic platelet accumulation. Attenuated the inflammatory response and apoptosis in the livers. Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).

Animal Model:	Burn injury model of C57BL/6 N mice^[4]
Dosage:	0.6 mg/kg for a single dose
Administration:	Intraperitoneal injection
Result:	Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.

Animal Model:	BALB/c mice^[6]
Dosage:	40 ng/kg for a single dose
Administration:	Intrapleural injection
Result:	Abolished the number of rolling and adhering neutrophils on the vessel wall. Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.

IC 50

PAR4

storage

Store at -20°C

TCY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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TCY-NH2 Suppliers

China 30 Germany 2 Switzerland 1 United Kingdom 1 United States 7 USA 1 Global 42

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327177-34-4, TCY-NH2Related Search:

Octanoic hydrazide Cinnamon oil N-ACETYLGLYCINAMIDE A-METHYL-N-(3-PHENYL-2-PROPENYL)BENZNEETHANAMINE TCY-NH2

TCY-NH2

TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2

TRANS-CINNAMOYL-YPGKF-AMIDE

M.W. 739.87 C40H49N7O7

trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt

trans-Cinnamoyl-YPGKF-NH2, tcY-NH2

trans-Cinnamoyl-YPGKF-NH2

L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-

Protease-Activated Receptor-4, PAR-4 Antagonist, amide - 1 mg

327177-34-4

C40H49N7O7

C40H50N7O7

Proteinase-activated receptor (PAR)