ChemicalBook > CAS DataBase List > TCY-NH2
TCY-NH2
- Product Name
- TCY-NH2
- CAS No.
- 327177-34-4
- Chemical Name
- TCY-NH2
- Synonyms
- TCY-NH2;M.W. 739.87 C40H49N7O7;trans-Cinnamoyl-YPGKF-NH2;TRANS-CINNAMOYL-YPGKF-AMIDE;trans-Cinnamoyl-YPGKF-NH2, tcY-NH2;TRANS-CINNAMOYL-TYR-PRO-GLY-LYS-PHE-NH2;Protease-Activated Receptor-4, PAR-4 Antagonist, amide - 1 mg;trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-amide trifluoroacetate salt;L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-
- CBNumber
- CB4157102
- Molecular Formula
- C40H49N7O7
- Formula Weight
- 739.86
- MOL File
- 327177-34-4.mol
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TCY-NH2 Property
- storage temp.
- −20°C
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
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Safety
- Safety Statements
- 22-24/25
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N-Bromosuccinimide Price
Tocris
- Product number
- 1488
- Product name
- tcY-NH2
- Packaging
- 1
- Price
- $219
- Updated
- 2021/12/16
Usbiological
- Product number
- 256892
- Product name
- tcY-NH2
- Packaging
- 1mg
- Price
- $466
- Updated
- 2021/12/16
TRC
- Product number
- N394025
- Product name
- tcY-NH2
- Packaging
- 1mg
- Price
- $200
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- PEP0004622
- Product name
- TCY-NH2
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.5
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5123
- Product name
- tcY-NH2
- Packaging
- 1mg
- Price
- $322
- Updated
- 2021/12/16
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TCY-NH2 Chemical Properties,Usage,Production
Uses
tcY-NH2 does not cause aggregation but blocks aggregation caused by receptor-activating peptide analogs (GY-NH2, AY-NH2), and thrombin without affecting ADP-mediated aggregation.
in vivo
tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model [4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].
| Animal Model: | Brain death (BD) rat model[3] |
| Dosage: | 0.6 mg/kg for a single dose |
| Administration: | Tail vein injection for a single dose |
| Result: | Reduced blood platelet activation and hepatic platelet accumulation. Attenuated the inflammatory response and apoptosis in the livers. Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD). |
| Animal Model: | Burn injury model of C57BL/6 N mice[4] |
| Dosage: | 0.6 mg/kg for a single dose |
| Administration: | Intraperitoneal injection |
| Result: | Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis. |
| Animal Model: | BALB/c mice[6] |
| Dosage: | 40 ng/kg for a single dose |
| Administration: | Intrapleural injection |
| Result: | Abolished the number of rolling and adhering neutrophils on the vessel wall. Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice. |
IC 50
PAR4
storage
Store at -20°C
TCY-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
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TCY-NH2 Suppliers
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TCY-NH2