METHYLDICHLOROPHOSPHINE Property

Melting point:

81.5 °C

Boiling point:

81-82 °C

Density 

1.3

refractive index 

1.4944-1.4964

Flash point:

48 °C

storage temp. 

Flammables area

form 

Liquid

color 

Colorless

Water Solubility 

Reacts with water.

Sensitive 

Air & Moisture Sensitive

EPA Substance Registry System

Methylphosphonous dichloride (676-83-5)

Safety

Hazard Codes 

T-F,T,F

Risk Statements 

34-29-23/24/25-17-14-10

Safety Statements 

8-45-43-36/37/39-33-26-16-23

RIDADR 

2845

WGK Germany 

3

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

I

HS Code 

29310099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H250Catches fire spontaneously if exposed to air

H252Self-heating in large quantities; may catch fire

H301Toxic if swalloed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H331Toxic if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P222Do not allow contact with air.

P231Handle under inert gas.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P422Store contents under …

METHYLDICHLOROPHOSPHINE Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

Methyldichlorophosphine is used to prepare difunctional phosphonoamidite coupling reagents in nucleoside chemistry and "phospha-Wittig"reagents.

General Description

A colorless liquid with a pungent odor. Very toxic by inhalation. Denser than water.

Air & Water Reactions

Highly flammable. Forms fumes containing HCl in moist air. Can spontaneously ignite on contact with moist air. Reacts with water to form hydrochloric acid, reaction may be violent and ignite unreacted material.

Reactivity Profile

METHYLDICHLOROPHOSPHINE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated.

Safety Profile

A poison. A corrosive irritant to the skin, eyes, and mucous membranes. Flammable when exposed to heat or flame; can react vigorously with oxidtzing materials. When heated to decomposition it emits very toxic fumes of Cland POx.