SL 327
- Product Name
- SL 327
- CAS No.
- 305350-87-2
- Chemical Name
- SL 327
- Synonyms
- SL 327;CS-1890;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;Mek-1/Mek-2 Inhibitor;MEK Inhibitor VII SL327 SL-327;SL327;SL-327;MEK-1/MEK-2 INHIBITOR;3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
- CBNumber
- CB4168773
- Molecular Formula
- C16H12F3N3S
- Formula Weight
- 335.35
- MOL File
- 305350-87-2.mol
SL 327 Property
- Melting point:
- 127-128.2 °C
- Boiling point:
- 512.6±50.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- 2-8°C
- solubility
- DMSO: 32 mg/mL
- form
- solid
- pka
- 3.42±0.10(Predicted)
- color
- white
Safety
- WGK Germany
- 3
- HS Code
- 2930909899
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S4069
- Product name
- SL327
- Purity
- ≥98% (HPLC), Mixture of E & Z isomers, solid
- Packaging
- 5mg
- Price
- $173
- Updated
- 2024/03/01
- Product number
- S4069
- Product name
- SL327
- Purity
- ≥98% (HPLC), Mixture of E & Z isomers, solid
- Packaging
- 25mg
- Price
- $251.2
- Updated
- 2024/03/01
- Product number
- 15598
- Product name
- SL 327
- Purity
- ≥95% (mixture of cis/trans isomers)
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 15598
- Product name
- SL 327
- Purity
- ≥95% (mixture of cis/trans isomers)
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15598
- Product name
- SL 327
- Purity
- ≥95% (mixture of cis/trans isomers)
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
SL 327 Chemical Properties,Usage,Production
Description
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-
Uses
SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.
Definition
ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Biological Activity
Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Biochem/physiol Actions
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
storage
+4°C (desiccate)
SL 327 Preparation Products And Raw materials
Raw materials
Preparation Products
SL 327 Suppliers
- Tel
- 4401179829988
- Fax
- 4402030 700 369
- customerservice@ascentscientific.co.uk
- Country
- United Kingdom
- ProdList
- 279
- Advantage
- 60
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from SL 327 manufacturers
- Product
- (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile 305350-87-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20