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Pemetrexed

Product Name
Pemetrexed
CAS No.
137281-23-3
Chemical Name
Pemetrexed
Synonyms
PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5
CBNumber
CB4170583
Molecular Formula
C20H21N5O6
Formula Weight
427.41
MOL File
137281-23-3.mol
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Pemetrexed Property

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
slightly sol. in Methanol
form 
powder to crystal
pka
3.58±0.10(Predicted)
color 
White to Blue
Merck 
14,7077
CAS DataBase Reference
137281-23-3(CAS DataBase Reference)
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Safety

RTECS 
LZ9950100
HS Code 
2933.99.9701
Hazardous Substances Data
137281-23-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2288
Product name
Pemetrexed Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
P2288
Product name
Pemetrexed Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$200
Updated
2024/03/01
Tocris
Product number
6185
Product name
Pemetrexed
Purity
≥98%(HPLC)
Packaging
50
Price
$63
Updated
2021/12/16
TRC
Product number
A604980
Product name
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicAcid
Packaging
250mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
BP164240
Product name
Pemetrexed
Packaging
100mg
Price
$135
Updated
2021/12/16
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Pemetrexed Chemical Properties,Usage,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

brand name

Alimta (Lilly).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

storage

Store at +4°C

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemetrexed Suppliers

Canada 2 China 260 China Hong Kong 1 Europe 1 France 2 Germany 4 India 46 Israel 1 Italy 2 Japan 1 South Korea 1 United Kingdom 7 United States 30 Global 358
Guangzhou Tomums Life Science Co., Ltd.
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J & K SCIENTIFIC LTD.
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Chembest Research Laboratories Limited
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Energy Chemical
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View Lastest Price from Pemetrexed manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
Pemetrexed 137281-23-3
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200
Release date
2024-01-22
Guangzhou PI PI BIOTECH INC
Product
Pemetrexed 137281-23-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2021-09-20
Hebei Mingeng Biotechnology Co., Ltd
Product
Pemetrexed Disodium 137281-23-3
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-28

137281-23-3, PemetrexedRelated Search:

Pemetrexed Disodium Pemetrexed disodium hemipentahydrate Pemetrexed Pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine CHEMBRDG-BB 9071517 2-AMINO-5-METHYL-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071469

  • (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid
  • PeMetrexed-13C5
  • PeMetrexed-15C5
  • N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid)
  • N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi
  • N-[4-[2-(2-Amino-4,7
  • (2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid
  • N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol...
  • PeMetrexed disodiuM INT-6
  • (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid
  • The sour sour of the United States
  • Pemetrexed Hydrate
  • Pemetrexed - Labeled 15N,13C5
  • (R)-Pemetrexed
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan
  • PEMETREXED ACID
  • PEMETREXED
  • N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
  • Pemetrexed99%
  • L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
  • PEFLOXACINMESYLATE
  • Premetred disodium
  • Pemetrexedum
  • Premetred
  • PemetrexedHydrate&gt
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL
  • )benzamido)pentanedioic acid
  • 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi...
  • PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed
  • PEMETREXED
  • Pemetrexedaci
  • 137281-23-3
  • C20H21N5O6xH2O
  • Anti-cancer & immunity
  • API
  • CIALIS