ChemicalBook > CAS DataBase List > Pemetrexed

Pemetrexed

Product Name
Pemetrexed
CAS No.
137281-23-3
Chemical Name
Pemetrexed
Synonyms
PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5
CBNumber
CB4170583
Molecular Formula
C20H21N5O6
Formula Weight
427.41
MOL File
137281-23-3.mol
More
Less

Pemetrexed Property

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
slightly sol. in Methanol
form 
powder to crystal
pka
3.58±0.10(Predicted)
color 
White to Blue
Merck 
14,7077
CAS DataBase Reference
137281-23-3(CAS DataBase Reference)
More
Less

Safety

RTECS 
LZ9950100
HS Code 
2933.99.9701
Hazardous Substances Data
137281-23-3(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
P2288
Product name
Pemetrexed Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
P2288
Product name
Pemetrexed Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$200
Updated
2024/03/01
Tocris
Product number
6185
Product name
Pemetrexed
Purity
≥98%(HPLC)
Packaging
50
Price
$63
Updated
2021/12/16
TRC
Product number
A604980
Product name
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicAcid
Packaging
250mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
BP164240
Product name
Pemetrexed
Packaging
100mg
Price
$135
Updated
2021/12/16
More
Less

Pemetrexed Chemical Properties,Usage,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

brand name

Alimta (Lilly).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

storage

Store at +4°C

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pemetrexed Suppliers

Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9499
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
More
Less

View Lastest Price from Pemetrexed manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
Pemetrexed 137281-23-3
Price
US $2.54/kg
Min. Order
1kg
Purity
99.49
Supply Ability
60 tons
Release date
2024-08-23
Hebei Weibang Biotechnology Co., Ltd
Product
PeMetrexed-13C5 137281-23-3
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2021-10-20
Guangzhou PI PI BIOTECH INC
Product
Pemetrexed 137281-23-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2021-09-20

137281-23-3, PemetrexedRelated Search:


  • (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid
  • PeMetrexed-13C5
  • PeMetrexed-15C5
  • N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid)
  • N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi
  • N-[4-[2-(2-Amino-4,7
  • (2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid
  • N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol...
  • PeMetrexed disodiuM INT-6
  • (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid
  • The sour sour of the United States
  • Pemetrexed Hydrate
  • Pemetrexed - Labeled 15N,13C5
  • (R)-Pemetrexed
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan
  • PEMETREXED ACID
  • PEMETREXED
  • N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
  • Pemetrexed99%
  • L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
  • PEFLOXACINMESYLATE
  • Premetred disodium
  • Pemetrexedum
  • Premetred
  • PemetrexedHydrate&gt
  • (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL
  • )benzamido)pentanedioic acid
  • 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi...
  • PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed
  • PEMETREXED
  • Pemetrexedaci
  • 137281-23-3
  • C20H21N5O6xH2O
  • Anti-cancer & immunity
  • API
  • CIALIS