2-(1-ADAMANTYL)-4-METHYLPHENOL Property

Melting point:

128-130 °C(lit.)

Boiling point:

359.9±21.0 °C(Predicted)

Density 

1.137±0.06 g/cm3 (20 ºC 760 Torr)

form 

Powder

pka

10.43±0.43(Predicted)

color 

White

Water Solubility 

Sparingly Soluble in water (7.8E-3 g/L) (25°C).

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2907290090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-(1-ADAMANTYL)-4-METHYLPHENOL Chemical Properties,Usage,Production

Uses

2-(1-Adamantyl)-4-methylphenol, is used as a pharmaceutical intermediate.

Uses

2-(1-Adamantyl)-4-methylphenol is a suitable starting reagent used in the synthesis of 2-(1-adamantyl)-4-methylthiophenol. It may also be used in the synthesis of 3-(1-adamantyl)-2-hydroxy-5-methylbenzaldehyde by reacting with urotropin. It may be used in the synthesis of adamantyl-substituted chromium(III) complex, a catalyst for enantioselective hetero-Diels-Alder reactions.

General Description

2-(1-Adamantyl)-4-methylphenol is a 2-adamantylphenol derivative. It has been synthesized by the adamantylation of p-cresol with 1-adamantanol. The structure has been confirmed by ¹H and ¹³C NMR.