Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- Product Name
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- CAS No.
- 106685-41-0
- Chemical Name
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- Synonyms
- Adapalene Methyl Ester;METHYL 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOATE;Methyl 6-(3-(adaMantan-1-yl)-4-Methoxyphenyl)-2-naphthoate;Adap-int C;Adapalene F;ADAPALENE RC B;Mehtyl 6-[3-(1-adama;Adapalene IMpurity E;Adapalene Impurity 5;Adapalene Impurity 6
- CBNumber
- CB8204103
- Molecular Formula
- C29H30O3
- Formula Weight
- 426.55
- MOL File
- 106685-41-0.mol
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Property
- Melting point:
- 223-225°C
- Boiling point:
- 589.6±50.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly)
- form
- solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR2828
- Product name
- Adapalene Related Compound B
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 100MG
- Price
- $592
- Updated
- 2025/07/31
- Product number
- 1011721
- Product name
- Adapalene Related Compound B
- Packaging
- 50mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- A225010
- Product name
- AdapaleneMethylEster
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- A225010
- Product name
- AdapaleneMethylEster
- Packaging
- 1g
- Price
- $545
- Updated
- 2021/12/16
- Product number
- A225010
- Product name
- AdapaleneMethylEster
- Packaging
- 2g
- Price
- $910
- Updated
- 2021/12/16
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
Adapalene intermediate
Synthesis
33626-98-1
104224-63-7
106685-41-0
General procedure for the preparation of methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthalenecarboxylate (V): magnesium scraps (1.26 g, 51.85 mmol) were mixed with THF (10 mL) under nitrogen protection and stirred at room temperature. 2-(1-adamantyl)-4-bromoanisole (IV) (1.4 g, 4.36 mmol) and 1,2-dibromoethane (0.56 mL) were added, and the reaction mixture was subsequently heated to 40 °C to initiate the reaction. Then a solution of 2-(1-adamantyl)-4-bromoanisole (12.6 g, 39.25 mmol) in THF (40 mL) was slowly added dropwise under reflux conditions for 30 min. A solution of purified zinc chloride (8.4 g, 61 mmol) in THF (30 mL) was added slowly dropwise at reflux temperature over 15 minutes. After the reaction mixture was refluxed for 1 h, methyl 6-bromo-2-naphthalenecarboxylate (8.0 g, 30 mmol) was added and stirred for 10 min, followed by the addition of NiCl2ZDPPE catalyst (0.21 g). The mixture was continued to be stirred at the same temperature for 2 h. The residue was subsequently concentrated. The residue was treated with dichloromethane (100 mL) and 1N HCl (100 mL), and the dichloromethane layer was washed sequentially with 10% EDTA disodium salt solution and water, dried with anhydrous sodium sulfate, and distilled to give the crude product. The crude product was stirred in ethyl acetate (140 mL) at 70 °C for 1 h, cooled to 15 °C and kept for 1 h. The solid was collected by filtration and dried. [Yield: 9.45 g, 50% yield].
References
[1] Organic Process Research and Development, 2006, vol. 10, # 2, p. 285 - 288
[2] Patent: WO2007/125542, 2007, A2. Location in patent: Page/Page column 16
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 26, p. 4993 - 5006
Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate manufacturers
- Product
- Dihydro-Axitinib 106685-41-0
- Price
- US $500.00/mg
- Min. Order
- 1mg
- Purity
- 99 %
- Supply Ability
- 500 Kg
- Release date
- 2025-09-15
- Product
- Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate 106685-41-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20