Diisobutylaluminium hydride
- Product Name
- Diisobutylaluminium hydride
- CAS No.
- 1191-15-7
- Chemical Name
- Diisobutylaluminium hydride
- Synonyms
- DIBAL-H;Dibal;DIISOBUTYLALUMINUM HYDRIDE;DIBAH;Diisobutylaluminum;Bis(2-methylpropyl)alumane;Bisisobutylaluminum;Diisobutylaluminum hydrid;diisobutylaluminum hydride solution;DiisobutylaluMinuM hydride solution 1.0 M in cyclohexane
- CBNumber
- CB4171924
- Molecular Formula
- C8H19Al
- Formula Weight
- 142.22
- MOL File
- 1191-15-7.mol
Diisobutylaluminium hydride Property
- Melting point:
- -70 °C
- Boiling point:
- 65 °C
- Density
- 1.23 g/mL at 25 °C
- vapor pressure
- 13.3Pa at 90℃
- Flash point:
- 40 °F
- storage temp.
- 2-8°C
- solubility
- Miscible with organic solvents.
- form
- Solution
- Specific Gravity
- 0.860
- color
- Clear
- Water Solubility
- vigorous reaction
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- Sensitive
- Air Sensitive/Heat Sensitive
- BRN
- 4123663
- Exposure limits
- ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) - InChIKey
- AZWXAPCAJCYGIA-UHFFFAOYSA-N
- LogP
- 4.22
- CAS DataBase Reference
- 1191-15-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Diisobutylaluminum hydride(1191-15-7)
- EPA Substance Registry System
- Diisobutylaluminum hydride (1191-15-7)
Safety
- Hazard Codes
- F,T,C,N
- Risk Statements
- 14/15-17-35-40-67-65-63-48/20-11-34-19-62-51/53-23/24/25-20/21/22-15-14-50/53-37-22
- Safety Statements
- 26-43-45-62-46-36/37/39-29-16-61-27-9
- RIDADR
- UN 3399 4.3/PG 1
- WGK Germany
- 2
- RTECS
- BD0710000
- F
- 1-4.3-10
- TSCA
- Yes
- HazardClass
- 4.3
- PackingGroup
- I
- HS Code
- 29319090
- Hazardous Substances Data
- 1191-15-7(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H250Catches fire spontaneously if exposed to air
H260In contact with water releases flammable gases which may ignite spontaneously
H304May be fatal if swallowed and enters airways
H314Causes severe skin burns and eye damage
H336May cause drowsiness or dizziness
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P231+P232Handle under inert gas. Protect from moisture.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
N-Bromosuccinimide Price
- Product number
- 214981
- Product name
- Diisobutylaluminum hydride solution
- Purity
- 1.0?M in THF
- Packaging
- 4X25ML
- Price
- $102
- Updated
- 2024/03/01
- Product number
- 214981
- Product name
- Diisobutylaluminum hydride solution
- Purity
- 1.0?M in THF
- Packaging
- 18L
- Price
- $2160
- Updated
- 2024/03/01
- Product number
- 190306
- Product name
- Diisobutylaluminum hydride solution
- Purity
- 1.0M in hexanes
- Packaging
- 100ml
- Price
- $62.6
- Updated
- 2024/03/01
- Product number
- 190306
- Product name
- Diisobutylaluminum hydride solution
- Purity
- 1.0M in hexanes
- Packaging
- 4x100ml
- Price
- $215
- Updated
- 2024/03/01
- Product number
- H37108
- Product name
- Diisobutylaluminumhydride,1.1Mincyclohexane
- Purity
- packagedunderNitrogeninresealableAcroSeal[tbottles
- Packaging
- 100ml
- Price
- $64.5
- Updated
- 2024/03/01
Diisobutylaluminium hydride Chemical Properties,Usage,Production
Description
Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2). It can be used for various homogeneous reductions such as alkynes to alkenes, esters or nitriles to aldehydes. It is available commercially as the neat reagent and as a solution in several different solvents (hexane, dichloromethane, tetrahydrofuran, etc.). The neat reagent is a liquid and is supplied in metal cylinders. It is pyrophoric and highly reactive and therefore must be handled with great care. The molar solutions in organic solvents are more stable and easier to handle provided that the normal precautions are taken for working with air-sensitive compounds. They must all be handled in an atmosphere free from oxygen and water. Commonly used solvents for diisobutylaluminium hydride are dichloromethane, diglyme, dioxane and tetrahydrofuran. Even when the substrate is not completely soluble in these solvents successful reductions can be accomplished.
Chemical Properties
Diisobutylaluminium hydride, also known as Dibal. colorless liquid. Viscosity 18.0mPa-s(25℃). Reacts violently with water to form hydrogen and isobutane. Tetrahydrofuran is not suitable as Dibal solvent, because the two react to produce coordination compounds. Diisobutylaluminium hydride is a useful reducing agent in organic synthesis. It can reduce ketones, carboxylic acids and esters to the corresponding alcohols. Dibal can also reduce lactones to o-hydroxy lactones.
Uses
Diisobutylaluminum hydride is commonly used as a reducing agent in organic synthesis.
Diisobutylaluminum hydride can be used in the following protocols:
As a promotor of Tishchenko reaction of aldehydes.
Conversion of benzylidene acetals of 1,2-and 1,3-glycols to the corresponding monobenzyl ethers of the glycols.
To generate a novel chiral reducing agent based on (S)-proline for the asymmetric reduction of prochiral ketones.
Uses
Diisobutylaluminum hydride is used as reducing agent in pharmaceuticals. It is also used as raw material in organic synthesis, agrochemicals and dyestuffs.
Uses
Diisobutylaluminum hydride (DIBAL-H) is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols. Some of the applications are:
Synthesis of α-acetoxy ethers by reduction and subsequent acetylation of esters.
Synthesis of coniferyl, sinapyl, and p-coumaryl alcohol by selective reduction of corresponding cinnamate esters.
Reduction of secondary phosphine oxides (SPOs) to the corresponding phosphines.
DIBAL-H can also be used in the hydroalumination of alkene and alkynes.
Flammability and Explosibility
Spontaneously flammable in air (pyrophoric)
Safety Profile
Mddly toxic by inhalation. Dangerous fire hazard; iptes spontaneously in air. To fight fire, do not use water, foam, or halogenated extinguisking agents. See also HYDRIDES and ALUMINUM COMPOUNDS.
Diisobutylaluminium hydride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diisobutylaluminium hydride manufacturers
- Product
- Diisobutylaluminium hydride 1191-15-7
- Price
- US $90.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-10
- Product
- Diisobutylaluminium hydride 1191-15-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2021-11-10
- Product
- Diisobutylaluminium hydride 1191-15-7
- Price
- US $1.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 20KG
- Release date
- 2018-08-06