1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

Product Name: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
CAS No.: 197638-83-8
Chemical Name: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
Synonyms: BUTTPARK 98\06-98;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE;4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE;1-boc-4-(4-formylphenyl)piperazine,97%;4-Piperazin-1-ylbenzaldehyde, N4-BOC protected;4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE;TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH;1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate;4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber: CB7157734
Molecular Formula: C16H22N2O3
Formula Weight: 290.36
MOL File: 197638-83-8.mol

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Property

Melting point:: 118-121 °C (lit.)
Boiling point:: 441.4±40.0 °C(Predicted)
Density: 1.154±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 2.45±0.10(Predicted)
Appearance: Light yellow to yellow Solid
Sensitive: Air Sensitive
InChI: InChI=1S/C16H22N2O3/c1-16(2,3)21-15(20)18-10-8-17(9-11-18)14-6-4-13(12-19)5-7-14/h4-7,12H,8-11H2,1-3H3
InChIKey: KHORERZDMJTBMR-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(C=O)C=C2)CC1

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Safety

Hazard Codes: T
Risk Statements: 25-43
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 651427
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Purity: 97%
Packaging: 1g
Price: $73.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 651427
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Purity: 97%
Packaging: 5g
Price: $240
Updated: 2023/06/20

TRC

Product number: B655953
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142626
Product name: tert-Butyl 4-(4-formylphenyl)piperazine-1-carboxylate
Packaging: 2g
Price: $51
Updated: 2021/12/16

AK Scientific

Product number: W4190
Product name: 1-Boc-4-(4-Formylphenyl)piperazine
Packaging: 1g
Price: $71
Updated: 2021/12/16

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

459-57-4

57260-71-6

197638-83-8

Step 1: Anhydrous potassium carbonate (8.5 g, 62 mmol) was added to a solution of N-methyl-2-pyrrolidinone (NMP, 30 mL) containing p-fluorobenzaldehyde (3.9 g, 31 mmol) and N-BOC-piperazine (6.3 g, 34 mmol) under nitrogen protection. The reaction mixture was stirred at 135 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was slowly poured into ice water (100 mL) and a yellow solid was precipitated. The precipitate was collected by filtration and washed three times (20 mL each) with cold water and dried under vacuum to give 1-BOC-4-(4-formylphenyl)piperazine as a yellow solid (6.4 g, 72% yield).

References

[1] Patent: WO2016/57779, 2016, A2. Location in patent: Page/Page column 68
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2747 - 2759
[3] Chemical Communications, 2016, vol. 52, # 67, p. 10289 - 10292
[4] Patent: WO2008/154642, 2008, A2. Location in patent: Page/Page column 155-156
[5] Patent: US2003/13737, 2003, A1

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

4-Fluorophenylacetonitrile Diisobutylaluminium hydride Toluene Potassium carbonate Chloroform Methanol Dimethyl sulfoxide 1-BOC-Piperazine Diisopropyl ether

Preparation Products

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Suppliers

Belgium 1 China 76 Germany 2 India 2 Switzerland 1 United Kingdom 7 United States 13 Global 102

Yantai Boyun Biological Technology Co. Ltd

Tel: 13793517650; 13793517650
Email: 2767277144@qq.com
Country: China
ProdList: 2856
Advantage: 58

Anhui Yongsheng Pharmaceutical Technology Co., Ltd

Tel: 181-3307-5798 18017383231
Email: 983544897@qq.com
Country: China
ProdList: 921
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai yirong biology science and technology co., ltd

Tel: 18049974220
Fax: +86 (21) 51062076
Email: 3060526242@qq.com
Country: China
ProdList: 995
Advantage: 60

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View Lastest Price from 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE manufacturers

Dideu Industries Group Limited

Product: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-23

Career Henan Chemical Co

Product: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-02

197638-83-8, 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINERelated Search:

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1-Boc-4-(2-formylphenyl)piperazine 1-Boc-4-(4-methoxycarbonylphenyl)piperazine 4-(BOC-PIPERAZIN-1-YL)-3-NITROBENZOIC A& 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE TERT-BUTYL 4-(4-CARBAMOYLPHENYL)PIPERAZINE-1-CARBOXYLATE 4-(4-ETHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(1-OXO-INDAN-5-YL)-PIPERAZINE

4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE

4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

1-(4-FORMYL-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

BUTTPARK 98\06-98

TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE

TERT-BUTYL 4-(4-FORMYLPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%

4-Piperazin-1-ylbenzaldehyde, N4-BOC protected

4-(N-Boc-piperazin-1-yl)benzaldehyde, tert-Butyl 4-(4μ-formylphenyl)piperazine-1-carboxylate

1-boc-4-(4-formylphenyl)piperazine,97%

4-(4-formylphenyl)-2-piperazinecarboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(4-formylphenyl)-, 1,1-dimethylethyl ester

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH

1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate

197638-83-8

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