4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

Product Name: 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
CAS No.: 162046-66-4
Chemical Name: 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
Synonyms: 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID;BUTTPARK 98\06-97;Boc-piperazine-benzoic acid;4-[N-Boc-piperazino]benzoic acid;4-(4-Boc-piperazin-1-yl)-benzoic a;4-(4-Boc-1-piperazinyl)benzoic Acid;4-(4-Boc-1-piperazineyl)benzoic acid;1-(4-carboxyphenyl)-4-Boc piperazine;1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE;1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID
CBNumber: CB6714965
Molecular Formula: C16H22N2O4
Formula Weight: 306.36
MOL File: 162046-66-4.mol

More

Less

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Property

Melting point:: 50 °C
Boiling point:: 476.9±40.0 °C(Predicted)
Density: 1.213±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 5.12±0.10(Predicted)
color: Off-white
CAS DataBase Reference: 162046-66-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39
Hazard Note: Harmful
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS007031
Product name: 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
Purity: Aldrich
Packaging: 10mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: B809938
Product name: 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-W0
Product name: 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Chem-Impex

Product number: 17231
Product name: 1-(4-Boc-piperazin-1-yl)benzoicacid,97%(HPLC)
Purity: 97%(HPLC)
Packaging: 1G
Price: $50.4
Updated: 2021/12/16

Matrix Scientific

Product number: 071857
Product name: 4-(4-Carboxyphenyl)piperazine-1-carboxylic acidtert-butyl ester
Purity: 95+%
Packaging: 1g
Price: $58
Updated: 2021/12/16

More

Less

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Chemical Properties,Usage,Production

Uses

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

Synthesis

158985-36-5

162046-66-4

General procedure for the synthesis of tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate from tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate: 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester (3.2 g, 10 mmol) was reacted with 2M NaOH solution (50 mL) in a mixture of THF (50 mL) and EtOH ( 50 mL) in a mixed solvent and the reaction was stirred at 60 °C for 3 hours. After completion of the reaction, the reaction mixture was concentrated to give a residue. The pH of the residue was adjusted to 7 with 2M HCl solution and filtered to afford tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate as a white solid (3.0 g, 100% yield).

References

[1] Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Preparation Products And Raw materials

Raw materials

Hexane Ethanol 4-Bromobenzonitrile Sodium sulfate Sodium chloride Potassium carbonate Fumaric acid Piperazine Ethyl acetate Hydrochloric acid Sodium bicarbonate Dichloromethane Isobutyric anhydride Sodium hydroxide Isopropyl alcohol

Preparation Products

More

Less

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Suppliers

Belgium 1 China 103 Germany 3 India 1 United Kingdom 8 United States 25 Global 141

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai Fei Yan Chemical Technology Co., Ltd.

Tel: 021-34663897 13816465839
Fax: 021-34663897
Email: 1141976404@qq.com
Country: China
ProdList: 41
Advantage: 57

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

More

Less

View Lastest Price from 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid manufacturers

Career Henan Chemical Co

Product: 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 162046-66-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2019-09-04

162046-66-4, 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acidRelated Search:

Levodropropizine N-Aminoethylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 2-Ethylhexyl ferulate 1-Boc-4-(4-methoxycarbonylphenyl)piperazine Carboxy styrene-butadiene latex 2-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER AQUANTRAAL BENZOICACID 4-(BOC-PIPERAZIN-1-YL)-3-NITROBENZOIC A& 4-(4-ETHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%

4-(4-Carboxyphenyl)piperazine, N1-BOC protected

4-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID

4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID

4-(4-TERT-BUTOXYCARBONYLPIPERAZINE)BENZOIC ACID

4-(4-CARBOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BUTTPARK 98\06-97

4-(4-tert-Butoxycarbonyl)piperazinebenzoic acid 97%

4-Piperazin-1-ylbenzoic acid, N4-BOC protected 97%

4-(4-Carboxy-phenyl)-piperazine-1-carboxylic acid

1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE

1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID

1-(4-CARBOXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID

4-(4-Carboxyphenyl)piperazine-1-carboxylicacidtert-butyleste

4-(4-Boc-1-piperazinyl)benzoic Acid

4-(4-Carboxyphenyl)piperazine, N1-BOC protected, tert-Butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate

4-[N-Boc-piperazino]benzoic acid

4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic Acid

4-(4-Boc-1-piperazineyl)benzoic acid

1-(4-carboxyphenyl)-4-Boc piperazine

(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid

1-Piperazinecarboxylic acid, 4-(4-carboxyphenyl)-, 1-(1,1-dimethylethyl) ester

Boc-piperazine-benzoic acid

4-(4-Boc-piperazin-1-yl)-benzoic a

4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid <i>tert</i>-butyl ester

1-(4-Boc-Piperazin-1-YL)-Benzoic Acid, 4-(4-Carboxy-Phenyl)-Piperazine-1-Carboxylic Acid Tert-Butyl Ester

162046-66-4

Building Blocks

C16 to C29

Chemical Synthesis

Heterocyclic Building Blocks

New Products for Chemical Synthesis

piperazines

API intermediates