ChemicalBook > CAS DataBase List > 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

Product Name
4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
CAS No.
162046-66-4
Chemical Name
4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid
Synonyms
4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID;BUTTPARK 98\06-97;Boc-piperazine-benzoic acid;4-[N-Boc-piperazino]benzoic acid;4-(4-Boc-piperazin-1-yl)-benzoic a;4-(4-Boc-1-piperazinyl)benzoic Acid;4-(4-Boc-1-piperazineyl)benzoic acid;1-(4-carboxyphenyl)-4-Boc piperazine;1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE;1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID
CBNumber
CB6714965
Molecular Formula
C16H22N2O4
Formula Weight
306.36
MOL File
162046-66-4.mol
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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Property

Melting point:
50 °C
Boiling point:
476.9±40.0 °C(Predicted)
Density 
1.213±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder
pka
5.12±0.10(Predicted)
color 
Off-white
CAS DataBase Reference
162046-66-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-26-36/37/39
Hazard Note 
Harmful
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS007031
Product name
4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
Purity
Aldrich
Packaging
10mg
Price
$73.1
Updated
2025/07/31
TRC
Product number
B809938
Product name
4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoicAcid
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50839
Product name
1-(4-Boc-piperazin-1-yl)benzoic acid
Packaging
1g
Price
$83.6
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-W0
Product name
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid
Purity
97%
Packaging
1g
Price
$88
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-W0
Product name
4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid
Purity
97%
Packaging
250mg
Price
$24
Updated
2021/12/16
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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Chemical Properties,Usage,Production

Uses

Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229)[1].

Synthesis

158985-36-5

162046-66-4

General procedure for the synthesis of tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate from tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate: 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester (3.2 g, 10 mmol) was reacted with 2M NaOH solution (50 mL) in a mixture of THF (50 mL) and EtOH ( 50 mL) in a mixed solvent and the reaction was stirred at 60 °C for 3 hours. After completion of the reaction, the reaction mixture was concentrated to give a residue. The pH of the residue was adjusted to 7 with 2M HCl solution and filtered to afford tert-butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate as a white solid (3.0 g, 100% yield).

References

[1] Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. J Med Chem. 2021;64(17):12831-12854.

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Preparation Products And Raw materials

Raw materials

Hexane Ethanol 4-Bromobenzonitrile Sodium sulfate Sodium chloride Potassium carbonate Fumaric acid Piperazine Ethyl acetate Hydrochloric acid Sodium bicarbonate Dichloromethane Isobutyric anhydride Sodium hydroxide Isopropyl alcohol

Preparation Products

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4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid Suppliers

Belgium 1 China 103 Germany 3 India 1 United Kingdom 8 United States 25 Global 141
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid manufacturers

Career Henan Chemical Co
Product
4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 162046-66-4
Price
US $5.00/KG
Min. Order
1KG
Purity
95%-98%
Supply Ability
100kg
Release date
2019-09-04

162046-66-4, 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acidRelated Search:

Levodropropizine N-Aminoethylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 2-Ethylhexyl ferulate 1-Boc-4-(4-methoxycarbonylphenyl)piperazine Carboxy styrene-butadiene latex 2-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER AQUANTRAAL BENZOICACID 4-(BOC-PIPERAZIN-1-YL)-3-NITROBENZOIC A& 4-(4-ETHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

  • 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid 97%
  • 4-(4-Carboxyphenyl)piperazine, N1-BOC protected
  • 4-[4-(TERT-BUTOXYCARBONYL)PIPERAZINO]BENZOIC ACID
  • 4-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)BENZOIC ACID
  • 4-(4-TERT-BUTOXYCARBONYLPIPERAZINE)BENZOIC ACID
  • 4-(4-CARBOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • BUTTPARK 98\06-97
  • 4-(4-tert-Butoxycarbonyl)piperazinebenzoic acid 97%
  • 4-Piperazin-1-ylbenzoic acid, N4-BOC protected 97%
  • 4-(4-Carboxy-phenyl)-piperazine-1-carboxylic acid
  • 1-BOC-4-(4-CARBOXY-PHENYL)-PIPERAZINE
  • 1-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID
  • 1-(4-CARBOXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-(4-BOC-PIPERAZIN-1-YL)-BENZOIC ACID
  • 4-(4-Carboxyphenyl)piperazine-1-carboxylicacidtert-butyleste
  • 4-(4-Boc-1-piperazinyl)benzoic Acid
  • 4-(4-Carboxyphenyl)piperazine, N1-BOC protected, tert-Butyl 4-(4-carboxyphenyl)piperazine-1-carboxylate
  • 4-[N-Boc-piperazino]benzoic acid
  • 4-[4-[(2-Methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic Acid
  • 4-(4-Boc-1-piperazineyl)benzoic acid
  • 1-(4-carboxyphenyl)-4-Boc piperazine
  • (4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid
  • 1-Piperazinecarboxylic acid, 4-(4-carboxyphenyl)-, 1-(1,1-dimethylethyl) ester
  • Boc-piperazine-benzoic acid
  • 4-(4-Boc-piperazin-1-yl)-benzoic a
  • 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid <i>tert</i>-butyl ester
  • 1-(4-Boc-Piperazin-1-YL)-Benzoic Acid, 4-(4-Carboxy-Phenyl)-Piperazine-1-Carboxylic Acid Tert-Butyl Ester
  • 162046-66-4
  • Building Blocks
  • C16 to C29
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • New Products for Chemical Synthesis
  • piperazines
  • API intermediates