4-Fluorophenylacetonitrile

Product Name: 4-Fluorophenylacetonitrile
CAS No.: 459-22-3
Chemical Name: 4-Fluorophenylacetonitrile
Synonyms: 4-Fluorobenzyl;AM0210000 [RTECS];4-Fluoroacetonitrile;4-FLUOROBENZYLNITRILE;P-FLUOROBENZYL CYANIDE;p-Fluorobenzyl nitrile;4-FLUOROBENZYL CYANIDE;4-FluorobenzylCyanide>4-Fluoroethylene nitrile;PARA-FLUOROBENZYL CYANIDE
CBNumber: CB3425068
Molecular Formula: C8H6FN
Formula Weight: 135.14
MOL File: 459-22-3.mol

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4-Fluorophenylacetonitrile Property

Melting point:: 86°C
Boiling point:: 119-120 °C/18 mmHg (lit.)
Density: 1.126 g/mL at 25 °C (lit.)
refractive index: n20/D 1.5002(lit.)
Flash point:: 227 °F
storage temp.: Inert atmosphere,Room Temperature
form: Liquid
color: Clear colorless to light yellow
BRN: 1907764
Exposure limits: NIOSH: IDLH 25 mg/m3
InChI: InChI=1S/C8H6FN/c9-8-3-1-7(2-4-8)5-6-10/h1-4H,5H2
InChIKey: JHQBLYITVCBGTO-UHFFFAOYSA-N
SMILES: C1(CC#N)=CC=C(F)C=C1
CAS DataBase Reference: 459-22-3(CAS DataBase Reference)
NIST Chemistry Reference: 4-Fluorophenylacetic acid nitrile(459-22-3)
EPA Substance Registry System: Benzeneacetonitrile, 4-fluoro- (459-22-3)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37/38-20/21/22/36/37/38-20/20/22
Safety Statements: 26-36-24/25-26/36/37/39
RIDADR: UN 3276 6.1/PG 3
WGK Germany: 3
RTECS: AM0210000
Hazard Note: Toxic
TSCA: TSCA listed
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 102407
Product name: 4-Fluorophenylacetonitrile
Purity: 99%
Packaging: 25g
Price: $85.1
Updated: 2026/04/30

Sigma-Aldrich

Product number: 102407
Product name: 4-Fluorophenylacetonitrile
Purity: 99%
Packaging: 100g
Price: $168
Updated: 2023/06/20

TCI Chemical

Product number: F0258
Product name: 4-Fluorobenzyl Cyanide
Purity: >98.0%(GC)
Packaging: 25g
Price: $31
Updated: 2026/04/30

TCI Chemical

Product number: F0258
Product name: 4-Fluorobenzyl Cyanide
Purity: >98.0%(GC)
Packaging: 250g
Price: $183
Updated: 2026/04/30

TRC

Product number: F595565
Product name: 4-Fluorophenylacetonitrile
Packaging: 5g
Price: $50
Updated: 2021/12/16

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4-Fluorophenylacetonitrile Chemical Properties,Usage,Production

Chemical Properties

Clear light yellow liquid

Uses

4-Fluorophenylacetonitrile is used as a reagent in the synthesis of novel Daidzein analogs which exhibit anti-influenza activity in vitro. It is also used as a reagent in the synthesis of benzylbenzo[d]thiazole sulfonamides which exhibit anti-inflammatory activity.

General Description

4-Fluorophenylacetonitrile is starting reagent in the synthesis of 1-Alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives.

Biochem/physiol Actions

4-Fluorophenylacetonitrile undergoes biotransformation to 4-Fluorophenylacetic acid by marine fungi, Aspergillus sydowii Ce19.

Synthesis

Add 0.3 mmol of cuprous iodide and 0.3 mL of toluene solvent to the reaction tube and stir for 1 min; then add 0.5 mmol of K4[Fe(CN)6], 1 mmol of p-fluorobenzyl chloride and 0.7 mL of toluene. After sealing the reaction tube, it was stirred at 180 C for 20 h. After the reaction system was cooled down to room temperature, 1 mL of dichloromethane solution of acetophenone (0.8 mmol/mL) was added as the internal standard, stirred well and left for more than 1 h. The supernatant was taken and analyzed by gas chromatography, and the yield of p-fluorophenylacetonitrile was 85%. The theoretical value of the molecular ion peak (M+) of p-fluorophenylacetonitrile was 135.05 and the measured value was 135.1.

4-Fluorophenylacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXANONE

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4-Fluorophenylacetonitrile Suppliers

Americas 1 Belgium 3 Canada 1 China 283 Europe 4 France 2 Germany 5 India 24 Italy 1 Japan 4 Poland 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 21 United States 52 Global 407

Nanjing Jubai Biomedical Technology Co., Ltd.

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View Lastest Price from 4-Fluorophenylacetonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluorophenylacetonitrile 459-22-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Fluorophenylacetonitrile 459-22-3
Price: US $10.70/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Honest Joy Holdings Limited

Product: 4-Fluorophenylacetonitrile 459-22-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.4%
Supply Ability: 100 tons
Release date: 2022-02-18

459-22-3, 4-FluorophenylacetonitrileRelated Search:

4-Fluorobenzaldehyde FLUCYTHRINATE Florfenicol Cyhalothrin 4-Fluorobenzoic acid 4-Fluorobenzyl chloride 4-Fluoroanisole 4-Fluorophenylacetic acid Transfluthrin 4'-Fluoropropiophenone p-Nitrophenylacetonitrile Copper(I) Cyanide Iminodiacetonitrile 4-Fluorophenethylamine 4-Chlorobenzyl cyanide 4-Fluorobenzonitrile 2-(Chloromethyl)benzonitrile λ-Cyhalothrin

P-FLUOROBENZYL CYANIDE

P-FLUOROPHENYLACETONITRILE

PARA-FLUOROBENZYL CYANIDE

p-Fluorobenzyl nitrile

4-Fluorophenylacetonitrile,4-Fluorobenzyl cyanide

4-Fluorophenylacetonitrile, 99% 25GR

The fluorine benzene acetonitrile

(p-fluorophenyl)-acetonitril

4-fluoro-benzeneacetonitril

4-Fluorobenzeneacetonitrile

4-Fluorophenylaceticacidnitrile

Acetonitrile, (p-fluorophenyl)-

Benzeneacetonitrile, 4-fluoro-

para-Fluorophenylacetonitrile

4-FLUOROPHENYLACETONITRILE

4-FLUOROBENZYL CYANIDE

4-FLUOROBENZYLNITRILE

4-Fluorobenzyl Cyanide p-Fluorobenzyl Cyanide

4-Fluorophenylacetonitrile,97%

4-Fluorobenzyl

4-Fluorophenylacetonitrile 98%

4-Fluorophenylacetonitrile98%

4-FLUOROPHENYLACETONITRILE, 99+%

4-Fluoroacetonitrile

4-FluorobenzylCyanide&gt

4-Fluoroethylene nitrile

AM0210000 [RTECS]

4-Fluorophenylacetonitrile,96%

459-22-3

459-52-3

FC8H4CH2CN

C8H6FN

ARYL ISOCYANATE

Building Blocks

C8 to C9

Organic Building Blocks

Nitrogen Compounds

Cyanides/Nitriles

Aromatic Nitriles

Nitrile

Fluorobenzene