1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

Product Name: 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
CAS No.: 139290-70-3
Chemical Name: 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
Synonyms: N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine;1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide;N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected;4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98%;ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid
CBNumber: CB7296576
Molecular Formula: C13H24N2O4
Formula Weight: 272.34
MOL File: 139290-70-3.mol

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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Property

Melting point:: 71.0 to 75.0 °C
Boiling point:: 150°C/0.9mmHg(lit.)
Density: 1.106±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form: Oil
pka: -2.31±0.40(Predicted)
color: Pale Yellow
InChI: InChI=1S/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-10(7-9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3
InChIKey: ITCQNWXLNZGEHP-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(N(OC)C)=O)CC1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00042
Product name: tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TCI Chemical

Product number: B3708
Product name: tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $133
Updated: 2025/07/31

TRC

Product number: B657170
Product name: N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
Packaging: 500mg
Price: $75
Updated: 2021/12/16

TRC

Product number: B657170
Product name: N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 068942
Product name: tert-Butyl 4-[methoxy(methyl)carbamoyl]-piperidine-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $29
Updated: 2021/12/16

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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

An intermediate in the production of IKK inhibitors, ERK inhibitors, p38 MAP kinase inhibitors and serotonin receptor antagonists

Synthesis

6638-79-5

84358-13-4

139290-70-3

The general procedure for the preparation of 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine from 1-Boc-4-piperidinecarboxylic acid (2.34 g, 10.2 mmol) and dimethylhydroxylamine hydrochloride (1.5 g, 15 mmol) in DMF (50 mL) was as follows: to a stirred 1-Boc-4-piperidinecarboxylic acid and dimethylhydroxylamine hydrochloride at room temperature in a suspension in DMF was added triethylamine (2.8 mL, 20 mmol). After stirring for 10 min, HOBt (1.62 g, 12 mmol) and EDCI (2.3 g, 12 mmol) were added sequentially. The reaction mixture was stirred overnight and subsequently concentrated. The concentrated residue was dissolved in 1N HCl (100 mL) and extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed sequentially with saturated NaHCO3 solution (50 mL), brine (50 mL), dried over MgSO4 and concentrated to give a colorless oily product (2.79 g, yield >100%). The product was characterized by 1H NMR (500 MHz, CDCl3) and MS (ESI+): 1H NMR δ 4.14 (m, 2H), 3.71 (s, 3H), 3.19 (s, 3H), 2.78 (m, 3H), 1.68 (m, 4H), 1.46 (s, 9H); MS (ESI+) m/z 217.72 (M+H+- Isobutene).

References

[1] Patent: US2004/14763, 2004, A1. Location in patent: Page 21
[2] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 38
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[5] Patent: WO2006/2434, 2006, A2. Location in patent: Page/Page column 39

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Suppliers

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View Lastest Price from 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine manufacturers

Career Henan Chemical Co

Product: 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 139290-70-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

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1-Piperidinecarboxylic acid, 4-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester

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1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide

1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide

4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester

ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

1,1-Dimethylethyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate

tert-Butyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate

139290-70-3

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