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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

Product Name
1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
CAS No.
139290-70-3
Chemical Name
1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
Synonyms
N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine;1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide;N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected;4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid;4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98%;ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid
CBNumber
CB7296576
Molecular Formula
C13H24N2O4
Formula Weight
272.34
MOL File
139290-70-3.mol
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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Property

Melting point:
71.0 to 75.0 °C
Boiling point:
150°C/0.9mmHg(lit.)
Density 
1.106±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form 
Oil
pka
-2.31±0.40(Predicted)
color 
Pale Yellow
InChI
InChI=1S/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-10(7-9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3
InChIKey
ITCQNWXLNZGEHP-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(C(N(OC)C)=O)CC1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00042
Product name
tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
Purity
Aldrich
Packaging
1g
Price
$259
Updated
2025/07/31
TCI Chemical
Product number
B3708
Product name
tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate
Purity
>98.0%(GC)
Packaging
1g
Price
$133
Updated
2025/07/31
TRC
Product number
B657170
Product name
N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
Packaging
500mg
Price
$75
Updated
2021/12/16
TRC
Product number
B657170
Product name
N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
Packaging
250mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
068942
Product name
tert-Butyl 4-[methoxy(methyl)carbamoyl]-piperidine-1-carboxylate
Purity
>95%
Packaging
1g
Price
$29
Updated
2021/12/16
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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

An intermediate in the production of IKK inhibitors, ERK inhibitors, p38 MAP kinase inhibitors and serotonin receptor antagonists

Synthesis

6638-79-5

84358-13-4

139290-70-3

The general procedure for the preparation of 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine from 1-Boc-4-piperidinecarboxylic acid (2.34 g, 10.2 mmol) and dimethylhydroxylamine hydrochloride (1.5 g, 15 mmol) in DMF (50 mL) was as follows: to a stirred 1-Boc-4-piperidinecarboxylic acid and dimethylhydroxylamine hydrochloride at room temperature in a suspension in DMF was added triethylamine (2.8 mL, 20 mmol). After stirring for 10 min, HOBt (1.62 g, 12 mmol) and EDCI (2.3 g, 12 mmol) were added sequentially. The reaction mixture was stirred overnight and subsequently concentrated. The concentrated residue was dissolved in 1N HCl (100 mL) and extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed sequentially with saturated NaHCO3 solution (50 mL), brine (50 mL), dried over MgSO4 and concentrated to give a colorless oily product (2.79 g, yield >100%). The product was characterized by 1H NMR (500 MHz, CDCl3) and MS (ESI+): 1H NMR δ 4.14 (m, 2H), 3.71 (s, 3H), 3.19 (s, 3H), 2.78 (m, 3H), 1.68 (m, 4H), 1.46 (s, 9H); MS (ESI+) m/z 217.72 (M+H+- Isobutene).

References

[1] Patent: US2004/14763, 2004, A1. Location in patent: Page 21
[2] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 38
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[5] Patent: WO2006/2434, 2006, A2. Location in patent: Page/Page column 39

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Suppliers

Americas 1 Belgium 1 Canada 2 China 132 Czech Republic 1 Europe 1 Germany 3 India 5 Japan 4 United Kingdom 7 United States 35 Global 192
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine manufacturers

Career Henan Chemical Co
Product
1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 139290-70-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

139290-70-3, 1-Boc-4-[methoxy(methyl)carbamoyl]piperidineRelated Search:

(Trifluoromethoxy)benzene 4-Aminobenzoic acid METSULFURON METHYL Kresoxim-methyl Urethane Methyl acetate RESMETHRIN Methyl anthranilate 4-Methoxybenzoic acid tert-Butyl peroxybenzoate POLYURETHANE Tribenuron methyl Methyl salicylate Thiophanate-methyl Methyl Methyl bromide Piperidine TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

  • N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE
  • TERT-BUTYL 4-(N-METHOXY-N-METHYLCARBAMOYL)PIPERIDINE-1-CARBOXYLATE
  • 1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE
  • 4-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester
  • tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
  • N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
  • 1,1-Dimethylethyl 4-[[methyl(methoxy)amino]carbonyl]-1-piperidinecarboxylate
  • tert-Butyl 4-(N-Methoxy-N-MethylcarbaMoyl)-1-piperidinecarboxylate
  • 4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected
  • tert-Butyl 4-[Methoxy(Methyl)-carbaMoyl]piperidin-1-carboxylate
  • 4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid
  • 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester 1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide 1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide 1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid
  • 1-Piperidinecarboxylic acid, 4-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester
  • <i>tert</i>-Butyl 4-(<i>N</i>-Methoxy-<i>N</i>-methylcarbamoyl)-1-piperidinecarboxylate
  • 1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine
  • 4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98%
  • tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate &gt
  • 1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid
  • 1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide
  • 1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide
  • 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester
  • ert-Butyl4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate
  • 1,1-Dimethylethyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate
  • tert-Butyl 4-[(methoxymethylamino)carbonyl]-1-piperidinecarboxylate
  • 139290-70-3
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