ChemicalBook > CAS DataBase List > 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

Product Name: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
CAS No.: 197638-83-8
Chemical Name: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
Synonyms: BUTTPARK 98\06-98;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE;4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE;1-boc-4-(4-formylphenyl)piperazine,97%;4-Piperazin-1-ylbenzaldehyde, N4-BOC protected;4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE;TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE;1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH;1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate;4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber: CB7157734
Molecular Formula: C16H22N2O3
Formula Weight: 290.36
MOL File: 197638-83-8.mol

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Property

Melting point:: 118-121 °C (lit.)
Boiling point:: 441.4±40.0 °C(Predicted)
Density: 1.154±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 2.45±0.10(Predicted)
Appearance: Light yellow to yellow Solid
Sensitive: Air Sensitive
InChI: InChI=1S/C16H22N2O3/c1-16(2,3)21-15(20)18-10-8-17(9-11-18)14-6-4-13(12-19)5-7-14/h4-7,12H,8-11H2,1-3H3
InChIKey: KHORERZDMJTBMR-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(C=O)C=C2)CC1

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Safety

Hazard Codes: T
Risk Statements: 25-43
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 651427
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Purity: 97%
Packaging: 1g
Price: $73.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 651427
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Purity: 97%
Packaging: 5g
Price: $240
Updated: 2023/06/20

TRC

Product number: B655953
Product name: 1-Boc-4-(4-formylphenyl)piperazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR14490
Product name: 4-Piperazin-1-ylbenzaldehyde,N4-BOCprotected
Packaging: 1g
Price: $93
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142626
Product name: tert-Butyl 4-(4-formylphenyl)piperazine-1-carboxylate
Packaging: 5G
Price: $101
Updated: 2021/12/16

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1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

459-57-4

57260-71-6

197638-83-8

Step 1: Anhydrous potassium carbonate (8.5 g, 62 mmol) was added to a solution of N-methyl-2-pyrrolidinone (NMP, 30 mL) containing p-fluorobenzaldehyde (3.9 g, 31 mmol) and N-BOC-piperazine (6.3 g, 34 mmol) under nitrogen protection. The reaction mixture was stirred at 135 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was slowly poured into ice water (100 mL) and a yellow solid was precipitated. The precipitate was collected by filtration and washed three times (20 mL each) with cold water and dried under vacuum to give 1-BOC-4-(4-formylphenyl)piperazine as a yellow solid (6.4 g, 72% yield).

References

[1] Patent: WO2016/57779, 2016, A2. Location in patent: Page/Page column 68
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2747 - 2759
[3] Chemical Communications, 2016, vol. 52, # 67, p. 10289 - 10292
[4] Patent: WO2008/154642, 2008, A2. Location in patent: Page/Page column 155-156
[5] Patent: US2003/13737, 2003, A1

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

4-Fluorophenylacetonitrile Diisobutylaluminium hydride Toluene Potassium carbonate Chloroform Methanol Dimethyl sulfoxide 1-BOC-Piperazine Diisopropyl ether

Preparation Products

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View Lastest Price from 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE manufacturers

Dideu Industries Group Limited

Product: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-23

Career Henan Chemical Co

Product: 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 197638-83-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-02

197638-83-8, 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINERelated Search:

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1-Boc-4-(2-formylphenyl)piperazine 1-Boc-4-(4-methoxycarbonylphenyl)piperazine 4-(BOC-PIPERAZIN-1-YL)-3-NITROBENZOIC A& 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid 4-(2-AMINO-4-METHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE TERT-BUTYL 4-(4-CARBAMOYLPHENYL)PIPERAZINE-1-CARBOXYLATE 4-(4-ETHOXYCARBONYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(1-OXO-INDAN-5-YL)-PIPERAZINE

4-(4-TERT-BUTOXYCARBONYL)PIPERAZINEBENZALDEHYDE

4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

1-(4-FORMYL-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

BUTTPARK 98\06-98

TERT-BUTYL 4-(4'-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE

TERT-BUTYL 4-(4-FORMYLPHENYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

4-(4-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%

4-Piperazin-1-ylbenzaldehyde, N4-BOC protected

4-(N-Boc-piperazin-1-yl)benzaldehyde, tert-Butyl 4-(4μ-formylphenyl)piperazine-1-carboxylate

1-boc-4-(4-formylphenyl)piperazine,97%

4-(4-formylphenyl)-2-piperazinecarboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(4-formylphenyl)-, 1,1-dimethylethyl ester

1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE ISO 9001：2015 REACH

1,1-Dimethylethyl 4-(4-formylphenyl)-1-piperazinecarboxylate

197638-83-8

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