1,2-Diphenylhydrazine

Product Name: 1,2-Diphenylhydrazine
CAS No.: 122-66-7
Chemical Name: 1,2-Diphenylhydrazine
Synonyms: NSC 3510;RCRA U-109;NCI-C01854;NCI-C-01845;1,2-Diphenyl;Hydrazobenzen;HYDRAZOBENZENE;n,n’-bianiline;N,N'-Bianiline;Hydroazobenzene
CBNumber: CB4172325
Molecular Formula: C12H12N2
Formula Weight: 184.24
MOL File: 122-66-7.mol

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1,2-Diphenylhydrazine Property

Melting point:: 123-126 °C(lit.)
Boiling point:: 308.2°C (rough estimate)
Density: 1,158 g/cm³
vapor pressure: 2.6 x 10^-5 mmHg at 25 °C (Mabey et al., 1982)
refractive index: 1.6266 (estimate)
storage temp.: Refrigerator
solubility: Soluble in ethanol (Weast, 1986).
pka: 3.02±0.70(Predicted)
form: solid
color: Colorless to pale yellow to orange crystals
Water Solubility: 221 mg/L at 25 °C (U.S. EPA, 1980a)
BRN: 639793
Stability:: Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKey: YBQZXXMEJHZYMB-UHFFFAOYSA-N
CAS DataBase Reference: 122-66-7(CAS DataBase Reference)
NIST Chemistry Reference: Hydrazine, 1,2-diphenyl-(122-66-7)
EPA Substance Registry System: 1,2-Diphenylhydrazine (122-66-7)

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Safety

Hazard Codes: T,N
Risk Statements: 45-22-50/53
Safety Statements: 53-45-60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: MW2625000
F: 10-23
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29280000
Hazardous Substances Data: 122-66-7(Hazardous Substances Data)
Toxicity: Acute oral LD50 for rats 301 mg/kg (quoted, RTECS, 1985).

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H350May cause cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 126721
Product name: Hydrazobenzene
Packaging: 25g
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: 442232-U
Product name: 1,2-Diphenylhydrazine
Purity: analytical standard, ampule of 100?mg
Packaging: 100mg
Price: $60
Updated: 2022/05/15

TCI Chemical

Product number: H0180
Product name: Hydrazobenzene
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $145
Updated: 2024/03/01

TCI Chemical

Product number: H0180
Product name: Hydrazobenzene
Purity: >98.0%(HPLC)
Packaging: 100g
Price: $567
Updated: 2024/03/01

Alfa Aesar

Product number: A18037
Product name: Hydrazobenzene, tech. 90%, remainder mainly azobenzene
Packaging: 25g
Price: $36.8
Updated: 2021/12/16

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1,2-Diphenylhydrazine Chemical Properties,Usage,Production

Description

Diphenylhydrazine is a man-made chemical that occurs in two isomeric forms: 1,1-diphenylhydrazine and 1,2-diphenylhdrazine. Diphenylhydrazine is produced by the reduction of nitrobenzene. Little or no information is available for 1,1-diphenylhydrazine. Most toxicological and use data pertain to 1,2-diphenylhydrazine.

Chemical Properties

yellow crystalline powder

Uses

Impurity in the production of Phenylbutazone (P319570). Hydrazobenzene is a metabolic intermediate of Azobenzene Carcinogenic

Uses

Formerly used as a starting material in the production of benzidine for dyes; production of certain drugs.

Uses

Previously, 1,2-diphenylhydrazine was used for producing benzidine that was used in the synthesis of benzidine-based dyes. However, these dyes are no longer produced in the United States. The primary use of 1,2-diphenylhydrazine is in the production of the anti-inflammatory agent phenylbutazone and sulfinpyrazone, a uricosuric agent.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 36, p. 1529, 1988 DOI: 10.1248/cpb.36.1529
Tetrahedron, 32, p. 2157, 1976 DOI: 10.1016/0040-4020(76)85128-9

General Description

Orange powder or a bright orange crystalline solid.

Air & Water Reactions

1,2-Diphenylhydrazine oxidizes in air. 1,2-Diphenylhydrazine decomposes in acid solutions. Insoluble in water.

Reactivity Profile

1,2-Diphenylhydrazine is a mild reducing agent. Incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. Interaction with perchloryl fluoride in the presence of a dilutent below 32°F has caused separation of explosive solids. Is readily oxidized by nitric acid, silver nitrate or permanganate. Is reduced under alkaline conditions .

Health Hazard

1,2-Diphenylhydrazine is a liver toxin in rodents and appears to be carcinogenic in experimental animals.

Fire Hazard

Flash point data for 1,2-Diphenylhydrazine are not available; however, 1,2-Diphenylhydrazine is probably combustible.

Potential Exposure

Tumorigen,Mutagen. 1,2-Diphenylhydrazine (DPH) is a precursor inthe manufacture of benzidine, an intermediate in the production of dyes. 1,2-Diphenylhydrazine is used in the synthesis of phenylbutazone, a potent anti-inflammatory(antiarthritic) drug. Manufacturers of dyes and pharmaceuticals are subject to occupational exposure. Groups workingin the laboratory and forensic medicine may also be subjectto 1,2-diphenylhydrazine exposure.

First aid

Skin Contact: Flood all areas of body thathave contacted the substance with water. Do not wait toremove contaminated clothing; do it under the water stream.Use soap to help assure removal. Isolate contaminatedclothing when removed to prevent contact by others. EyeContact: Remove any contact lenses at once. Flush eyeswell with copious quantities of water or normal saline for atleast 2030 min. Seek medical attention. Inhalation: Leavecontaminated area immediately; breathe fresh air. Properrespiratory protection must be supplied to any rescuers. Ifcoughing, difficult breathing, or any other symptomsdevelop, seek medical attention at once, even if symptomsdevelop many hours after exposure. Ingestion: If convulsions are not present, give a glass or two of water or milk todilute the substance. Assure that the person’s airway isunobstructed and contact a hospital or poison center imm

Carcinogenicity

Hydrazobenzene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Biological. When 5 and 10 mg/L of diphenylhydrazine was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum, 80 and 72% biodegradation, respectively, were observed after 7 d (Tabak et al., 1981).
Chemical/Physical. Wet oxidation of 1,2-diphenylhydrazine at 320 °C yielded formic and acetic acids (Randall and Knopp, 1980). 1,2-Diphenylhydrazine will not hydrolyze (Kollig, 1993).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 16,000, 160, 1.5, and 0.015 mg/g, respectively (Dobbs and Cohen, 1980).

storage

Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Store under nitrogenaway from oxidizers, strong acids, acid chlorides, acidanhydrides. A regulated, marked area should be establishedwhere this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.

Shipping

The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21]

Purification Methods

Crystallise hydrazobenzene from hot EtOH containing a little ammonium sulfide or H2SO3 (to prevent atmospheric oxidation), preferably under N2. Dry it in a vacuum desiccator, and store it in the dark or under N2. Alternatively, crystallise it from pet ether (b 60-100o) to constant absorption spectrum. It is almost colourless but in air it turns yellow, then red with the formation of azobenzene. The hydrochloride crystallises from EtOH and has m 163-164o(dec); however, hydrazobenzene readily rearranges to benzidine in the presence of acid. The picrate crystallises from *C6H6 and has m 123o(dec). [Beilstein 15 H 123.]

Toxicity evaluation

The mechanism of action of diphenylhydrazine is not known. It is possible that some toxic effects may be attributed to its major metabolites, aniline and azobenzene, both of which are known carcinogens. Results of metabolism studies reporting aniline, benzidine, hyroxybenzidines, and aminophenols as metabolites in rats following multiple routes of administration suggest that the diphenylhydrazine metabolism may be similar to that of azobenzene and aniline. It is also possible that conversion of 1,2-diphenylhydrazine to aniline in the gastrointestinal tract may occur due to intestinal microflora and via acid hydrolysis.

Incompatibilities

Not compatible with oxidizers, strongacids, acid chlorides, acid anhydrides, and mineral acidsforming benzidine. Store under nitrogen.

1,2-Diphenylhydrazine Preparation Products And Raw materials

Raw materials

ZINC Silicon

Preparation Products

Phenylbutazone disperse Yellow RGFL Benzidine Pigment Yellow 12

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View Lastest Price from 1,2-Diphenylhydrazine manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Hydrazobenzene 122-66-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Career Henan Chemical Co

Product: Hydrazobenzene 122-66-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 434
Release date: 2019-09-01

122-66-7, 1,2-DiphenylhydrazineRelated Search:

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SYM-DIPHENYLHYDRAZINE

HYDRAZOBENZENE

1,2-DIPHENYLHYDRAZINE

1,2-DIPHENYLDIAZANE

Hydrazobenzene solution

1.2-Diphenylhydrazine 100mg [122-66-7]

Hydrazobenzene,N,N′-Diphenylhydrazine

sym-DIPHENYLHYDRAZINE, PRACT

1,2-dinitrophenylhydrazine

2-Diphenylhydrazine

NCI-C-01845

RCRA U-109

1,2-Diphenylhydrazine,97%

Hydrazobenzene, 95%, remainder mainly azobenzene

Hydrazobenzene, tech. 90%, remainder mainly azobenzene

NSC 3510

1,2-Diphenylhydrazine，N,N-diphenylhydrazine

1,1’-hydrazobis-benzen

1,1’-hydrazodibenzene

1,2-diphenyl-hydrazin

Benzene, 1,1'-hydrazobis-

Benzene, hydrazodi-

hydrazine,1,2-diphenyl-

Hydrazobenzen

hydrazobenzen(czech)

hydrazobenzene(1,2-diphenylhydrazine)

hydrazodi-benzen

Hydrazodibenzene

Hydroazobenzene

n,n’-bianiline

N,N’-biphenylhydrazine

N,N'-Bianiline

NCI-C01854

Rcra waste number U109

rcrawastenumberu109

symmetricaldiphenylhydrazine

1,2-Diphenyldrazine

Diphenylhydrazine, 1,2-? DPH

1,2-DIPHENYLHYDRAZINE, 100MG, NEAT

sym-Diphenylhydrazine, techn., 85%

N,N<sup>'</sup>-diphenylhydrazine

N,Nμ-Diphenylhydrazine, Hydrazobenzene

sym-N,N'-Diphenylhydrazine

1,2-Diphenyl

1,2-DIPHENYLHYDRAZINE/ PHENYLBUTAZONE

1,2-Diphenyhydrazine

HYDRAZOBENZENE: TECH., 86%

N,N'-Diphenylhydrazine

Hydrazobenzene&gt

1,2-Diphenyldiazane (1,2-Diphenylhy

Hydrazobenzene ISO 9001：2015 REACH

1,2-diphenylhydrazine ( Hydrazobenzene )

TIANFUCHEM--122-66-7-- 1,2-Diphenylhydrazine

Hydrazobenzene (8CI)

C6H5-NH-NH-C6H5:1,2-diphenyldiazane(1,2-diphenylhydrazine)

Phenylbutazone Impurity C

Butazone EP Impurity C

1,2-Diphenyldiazane (1,2-Diphenylhydrazine)