H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2
- Product Name
- H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2
- CAS No.
- 258276-95-8
- Chemical Name
- H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2
- Synonyms
- SCSLPQTSGLQKPES;LEP (116-130) (mouse);LEPTIN (116-130) MOUSE;Mouse leptin(116-130) amide;LEPTIN (116-130) AMIDE (MOUSE);obese gene peptide 116-130 amide;LEPTIN FRAGMENT 116-130 AMIDE, MOUSE;OBESE GENE PEPTIDE (116-130) AMIDE (MOUSE);Leptin fragment 116-130 amide mouse, >95%(HPLC);SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER
- CBNumber
- CB4178660
- Molecular Formula
- C64H109N19O24S
- Formula Weight
- 1560.73
- MOL File
- 258276-95-8.mol
H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Property
- Boiling point:
- 2035.4±65.0 °C(Predicted)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- insoluble in EtOH; ≥156 mg/mL in DMSO; ≥24.15 mg/mL in H2O
- form
- white powder
- pka
- 4.44±0.10(Predicted)
- color
- White to off-white
- Sequence
- H-Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-OH
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 2985
- Product name
- LEP(116-130)(mouse)
- Packaging
- 1
- Price
- $235
- Updated
- 2021/12/16
- Product number
- A1024
- Product name
- LEP(116-130)(mouse)
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- A1024
- Product name
- LEP(116-130)(mouse)
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- A1024
- Product name
- LEP(116-130)(mouse)
- Packaging
- 25mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- PEP0002368
- Product name
- LEPTIN (116-130), MOUSE
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $643.91
- Updated
- 2021/12/16
H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Chemical Properties,Usage,Production
Biological Activity
leptin (116-130), amide, mouse(c64h109n19o24s),a peptide with the sequence ser-cys-ser-leu-pro-gln-thr-ser-gly-leu-gln-lys-pro-glu-ser-nh2. leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. since the discovery of leptin, the breadth of biological actions has dramatically expanded and served to broaden the initial perspective, where this protein was viewed solely as an antiobesity hormone. important biological activities have been discovered in peripheral tissues that demonstrate the pleiotropic effects of this molecule in such areas as hematopoiesis, angiogenesis, blood pressure, bone mass, lymphoid organ homeostasis, and t lymphocyte function. recent data indicate that leptin(116-130), an active fragment of the native molecule, exerts effects similar to those of the native peptide on body weight and food intake.figure1 formula of leptin (116-130)figure2 signal transduction pathways of leptin
References
1. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW (May 1997). "Crystalstructure of the obese protein leptin-E100". Nature 387 (6629): 206–9.2. Brennan AM, Mantzoros CS (June 2006). "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications". Nat Clin Pract Endocrinol Metab 2 (6): 318–327. 3. GreGreen ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC Jr, Leibel RL, Weissenbach J, Friedman JM (August 1995). "The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7". Genome Res. 5 (1): 5–12.4. Margetic S, Gazzola C, Pegg GG, Hill RA (2002). "Leptin: a review of its peripheral actions and interactions". Int. J. Obes. Relat. Metab. Disord. 26 (11): 1407–1433.
H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Preparation Products And Raw materials
Raw materials
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View Lastest Price from H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 manufacturers
- Product
- H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 258276-95-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16