Definition Pharmaceutical Properties
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CALYCOSIN

Definition Pharmaceutical Properties
Product Name
CALYCOSIN
CAS No.
20575-57-9
Chemical Name
CALYCOSIN
Synonyms
Clycosin;CALYCOSIN;CALYCOSIN(SH);Astraisoflavone;Calycosin 20575-57-9;Calycosin (Cyclosin);3'-HYDROXYFORMONONETIN;Calycosin >=98% (HPLC);Balofloxacin Impurity 8;3',7-DIHYDROXY-4'-METHOXYISOFLAVONE
CBNumber
CB4182878
Molecular Formula
C16H12O5
Formula Weight
284.26
MOL File
20575-57-9.mol
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CALYCOSIN Property

Melting point:
245～247℃
Boiling point:
536.8±50.0 °C(Predicted)
Density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
methanol: soluble1mg/mL, clear, colorless
pka
6.94±0.20(Predicted)
form 
powder
color 
white to light yellow
InChIKey
ZZAJQOPSWWVMBI-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
HS Code 
2932996560
Hazardous Substances Data
20575-57-9(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82491
Product name
Calycosin
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$629
Updated
2024/03/01
Sigma-Aldrich
Product number
1087472
Product name
Calycosin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
25091
Product name
Calycosin
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
25091
Product name
Calycosin
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
B9938
Product name
Calycosin
Purity
≥98% (HPLC)
Packaging
10mg
Price
$350
Updated
2024/03/01
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CALYCOSIN Chemical Properties,Usage,Production

Definition

Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus and Trifolium pratense L. Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It derives from an isoflavone. It is a conjugate acid of a calycosin(1-).

Pharmaceutical Properties

The potential pharmaceutical properties of calycosin in the treatment of tumors, inflammation, stroke, and cardiovascular diseases have gained increasing attention in the recent years. The literature survey showed that calycosin exhibits promising effects for the treatment of several diseases and that these effects may be due to its isoflavonoid and phytoestrogenic properties. The effects of calycosin most likely result from its interaction with the ER receptors on the cell membrane and the modulation of the MAPK signaling pathway.
Through its effect on this pathway, calycosin can regulate several cell activities, such as apoptosis and angiogenesis, which enables its therapeutic functions. 

Uses

Calycosin is a known antioxidant that prevent redox imbalance in organisms. Also, it possesses anti-tumor, anti-inflammation and osteogenic properties; Useful as a therapeutic reagent for bone loss-associated diseases.

Definition

ChEBI: Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).

CALYCOSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CALYCOSIN manufacturers

Hebei Dangtong Import and export Co LTD
Product
CALYCOSIN 20575-57-9
Price
US $510.00-470.00/Grams
Min. Order
10Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-21
Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Calycosin 20575-57-9
Price
US $100.00-30.00/kg
Min. Order
1kg
Purity
99.93%
Supply Ability
1000kg per week
Release date
2024-04-24
Henan Bao Enluo International TradeCo.，LTD
Product
CALYCOSIN 20575-57-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-18

20575-57-9, CALYCOSINRelated Search:

Verbascoside CALYCOSIN 7-O-GLUCOSIDE CALYCOSIN 5-HYDROXYDEQUELIN Isoflavone PSEUDOBAPTIGENIN-7-GLUCOSIDE 4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7-methoxy- 6-HYDROXY-7-METHOXY-3',4'-METHYLENEDIOXYISOFLAVONE OROBOL 7,4'-DIMETHYL ETHER PSEUDOBAPTIGENIN 3',4'-DIMETHOXY-7-HYDROXYISOFLAVONE PRATENSEIN FUJIKINETIN Calycosin-O-β-D-glucopyranoside CALYCOSIN(RG) AKOS 212-61 DEMETHYLACICERONE POMIFERIN-3',4'-DIMETHYL ETHER

  • CALYCOSIN
  • 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE
  • 3'-HYDROXYFORMONONETIN
  • 3',7-DIHYDROXY-4'-METHOXYISOFLAVONE
  • 3-(3-Hydroxy-4-methoxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
  • 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • Astraisoflavone
  • Clycosin
  • CALYCOSIN(SH)
  • Calycosin 20575-57-9
  • 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1-benzopyran-4-one
  • Calycosin, 98%, from Astragalus membranaceus Bunge
  • 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
  • Calycosin (Cyclosin)
  • 4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-
  • Calycosin >=98% (HPLC)
  • 3',7-Dihydroxy-4'-methoxy-isoflavone7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one
  • 7,3'-dihydroxy-4'-methoxyisoflavanon-2-ene
  • 7,5'-dihydroxy-4'-methoxyisoflavone
  • 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-
  • 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one4H-1-Benzopyran-4-one
  • 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one[Cyclosin]
  • Balofloxacin Impurity 8
  • 20575-57-9
  • C16H12O5
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • reference substance
  • Iso-Flavones
  • The group of Astralosides