Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
- Product Name
- Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
- CAS No.
- 341001-38-5
- Chemical Name
- Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
- Synonyms
- CS-681;Nucleozin;Nucleozin, 10 mM in DMSO;Nucleozin >=98% (HPLC), powder;1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine;[4-(2-Chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)methanone;Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-;[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone;inhibit,Nucleozin,viral,Inhibitor,infection,Influenza Virus,nuclear,nucleoprotein,virus,replication,accumulation
- CBNumber
- CB41872343
- Molecular Formula
- C21H19ClN4O4
- Formula Weight
- 426.85
- MOL File
- 341001-38-5.mol
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Property
- Density
- 1.371
- storage temp.
- 2-8°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- color
- yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N2790
- Product name
- Nucleozin
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $103
- Updated
- 2024/03/01
- Product number
- N2790
- Product name
- Nucleozin
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $391
- Updated
- 2024/03/01
- Product number
- 492905
- Product name
- Nucleozin
- Purity
- A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.
- Packaging
- 25MG
- Price
- $251
- Updated
- 2024/03/01
- Product number
- CS-0099
- Product name
- Nucleozin
- Purity
- 99.74%
- Packaging
- 10mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-0099
- Product name
- Nucleozin
- Purity
- 99.74%
- Packaging
- 25mg
- Price
- $216
- Updated
- 2021/12/16
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Chemical Properties,Usage,Production
Uses
Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.
Biological Activity
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.', 'Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.
target
Influenza Virus NP
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Suppliers
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