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BENPROPERINE

Product Name
BENPROPERINE
CAS No.
2156-27-6
Chemical Name
BENPROPERINE
Synonyms
pirexyl;Benproperin;BRN 1258822;BRN-1258822;BENPROPERINE;Bemproperina;Benproperinum;Benproperine Monomer;BENPROPERINE USP/EP/BP;1-(2-Benzylphenoxy)-2-piperidinopropane
CBNumber
CB4187277
Molecular Formula
C21H27NO
Formula Weight
309.45
MOL File
2156-27-6.mol
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BENPROPERINE Property

Boiling point:
bp0.2 159-161°
Density 
1.0350 (rough estimate)
refractive index 
1.5614 (estimate)
solubility 
DMSO:1.0(Max Conc. mg/mL);3.23(Max Conc. mM)
PBS (pH:7.2):1.0(Max Conc. mg/mL);3.23(Max Conc. mM)
pka
9.46±0.50(Predicted)
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Safety

Toxicity
LD50 orally in mice: 1087 mg/kg (Tellini, De Fina)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0007942
Product name
BENPROPERINE
Purity
95.00%
Packaging
5MG
Price
$505.98
Updated
2021/12/16
AvaChem
Product number
1567B
Product name
Benproperine
Packaging
50mg
Price
$129
Updated
2021/12/16
AvaChem
Product number
1567B
Product name
Benproperine
Packaging
1g
Price
$259
Updated
2021/12/16
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BENPROPERINE Chemical Properties,Usage,Production

Originator

Tussafug,Medipharm,Switz.

Definition

ChEBI: 1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine is a diarylmethane.

Manufacturing Process

A mixture of 26.1 g of o-benzylphenoxy-β-chloropropane and 17 g of piperidine is refluxed over a period of 32 hours until the temperature is about 124°C and a nearly solid mixture is formed due to the precipitation of a salt. The mixture is then refluxed over a period of 48 hours at about 160°C and the reaction product obtained is cooled and dissolved in methanol. The solution is concentrated under reduced pressure to yield an oil which is added to 200 ml 3N hydrochloric acid whereupon the mixture is shaken with ether, 3 x 100 ml, until the aqueous phase is clear. The ether solution is washed with water, 3 x 50 ml, and the water present in the combined aqueous phase and water used for washing is evaporated under reduced pressure methanol being added three times when the residue appears to be dry. The impure hydrochloride of o-benzylphenoxy-β-N-piperidinopropane, 41 g, obtained is dissolved in 100 ml water and 100 ml 30% aqueous sodium hydroxide solution are added, whereupon precipitated oil is extracted with ether, 1 x 100 and 2 x 50 ml. The ether solution is washed with water, 4 x 50 ml, dried with magnesium sulfate and the ether is removed under reduced pressure. The residue, 25.2 g, is distilled under reduced pressure and the main fraction, 23.2 g, BP 159°-161°C/0.2 mm.

Therapeutic Function

Antitussive

BENPROPERINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENPROPERINE Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from BENPROPERINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Benproperine 156-27-6
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-04-24
Dideu Industries Group Limited
Product
BENPROPERINE 2156-27-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100Tons min
Release date
2021-06-10
Career Henan Chemical Co
Product
BENPROPERINE 2156-27-6
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-12

2156-27-6, BENPROPERINERelated Search:


  • BENPROPERINE
  • 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)-piperidin
  • 1-(1-methyl-2-((alpha-phenyl-o-tolyl)oxy)ethyl)piperidine
  • 1-(1-methyl-2-(2-(phenylmethyl)phenoxy)ethyl)-piperidin
  • 1-(2-(2-benzilfenossi)-1-metiletil)-piperidina
  • pirexyl
  • Benproperin
  • 1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine
  • Piperidine, 1-[1-methyl-2-[(a-phenyl-o-tolyl)oxy]ethyl]- (7CI, 8CI)
  • Piperidine, 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-
  • 1-(2-Benzylphenoxy)-2-piperidinopropane
  • 1-[1-Methyl-2-[(α-phenyl-o-tolyl)oxy]ethyl]piperidine
  • BENPROPERINE USP/EP/BP
  • Bemproperina
  • Benproperinum
  • BRN 1258822
  • BRN-1258822
  • Benproperine Monomer
  • 2156-27-6
  • 156-27-6