ChemicalBook > CAS DataBase List > Z-NVA-OH

Z-NVA-OH

Product Name
Z-NVA-OH
CAS No.
21691-44-1
Chemical Name
Z-NVA-OH
Synonyms
Z-NVA-OH;Cbz-Nva-OH;Z-L-Nva-OH;Z-NORVALINE;Z-APE(2)-OH;CBZ-L-NVA-OH;Z-L-NORVALINE;Z-Nva-OH ,98%;CBZ-L-NORVALINE;Z-L-norvaline99%
CBNumber
CB4187707
Molecular Formula
C13H17NO4
Formula Weight
251.28
MOL File
21691-44-1.mol
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Z-NVA-OH Property

Boiling point:
439.4±38.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.00±0.20(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
21691-44-1(CAS DataBase Reference)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological
Product number
285602
Product name
Z-L-norvaline
Packaging
10g
Price
$363
Updated
2021/12/16
Activate Scientific
Product number
AS29383
Product name
N-Cbz-L-norvaline
Purity
95+% ee
Packaging
5G
Price
$57
Updated
2021/12/16
SynQuest Laboratories
Product number
4158-1-S4
Product name
Cbz-L-Norvaline
Packaging
5G
Price
$88
Updated
2021/12/16
Iris Biotech GmbH
Product number
ZAA1233
Product name
Z-L-Nva-OH
Packaging
5G
Price
$101.25
Updated
2021/12/16
Activate Scientific
Product number
AS29383
Product name
N-Cbz-L-norvaline
Purity
95+% ee
Packaging
25g
Price
$127
Updated
2021/12/16
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Z-NVA-OH Chemical Properties,Usage,Production

Uses

Z-NVA-OH is also known as Cbz-L-norvaline. It could be used to synthesise Z-Nva-Ser(Bu’)-Gly-OPh. In specific steps, as follows: the protected dipeptide(53.1 g. 124mM) and Tos.OH.H2O (33.6g. 124mM) were dissolved in DMF (200) and hydrogenolysed overnight in the presence of 10% Pd/C (6g), then filtered and concentrated to 100ml. Z-Nva-OH (37.4g. 149mM) was dissolved in CH2Cl2 (170ml) and NMM (16.4ml. 149mM) added. After cooling to -20℃, pivaloyl chloride (17.8ml. 145 mM) was added, and the solution was stirred for 20 minutes before the precooled DMF solution from above was added. Following the addition of NMM (13.6 ml, 124 mM), the reaction was stirred at - 20℃ for 3 hr, then maintained at room temperature overnight. The solution was evaporated, and the product dissolved in EtOAc. Washing with acid and base in the usual way, followed by crystallisation from EtOAc/petroleum ether yielded Z-Nva-Ser(Bu’)-Gly-OPh[1].

References

[1] I.J. Galpin. “Peptides—XXXXII.” Tetrahedron 37 17 (1981): Pages 3017-3023.

Z-NVA-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-NVA-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Z-NVA-OH 21691-44-1
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
99.0%min
Supply Ability
500kgs
Release date
2021-08-23
Career Henan Chemical Co
Product
Z-NVA-OH 21691-44-1
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-31

21691-44-1, Z-NVA-OHRelated Search:

N-Benzyloxycarbonyl-N'-(tert-Butoxycarbonyl)-L-lysine N-Cbz-L-Aspartic acid 4-benzyl ester Z-N-ME-GLU(OTBU)-OH Z-NVA-OSU Cbz-Valine ganciclovir 9-MethoxyMethyl Guanine N-Carboxybenzyl D-Valacyclovir S, S-Isovalganciclovir Impurity Ganciclovir Impurity 3 Valaciclovir EP Impurity H N-t-Boc-valacyclovir N-Methyl Valganciclovir Hydrochloride [2-(2-Amino-6-chloro-9H-purin-9-yl)ethyl]propanedioic acid dimethyl ester N-ForMyl Valacyclovir N-T-BOC-VALACYCLOVIR-D4 H-MEVAL-OH HCL Valaciclovir Ep Impurity C 194155-99-2

  • BENZYLOXYCARBONYL-L-NORVALINE
  • Norvaline reference substance
  • CBZ-L-NORVALINE
  • Z-APE(2)-OH
  • Z-L-ALPHA-AMINOVALERIC ACID
  • Z-L-2-AMINOVALERIC ACID
  • Z-NVA-OH
  • Z-NORVALINE
  • Z-L-NHCH[CH3(CH2)2]-COOH
  • Z-L-NORVALINE
  • RARECHEM AL CF 0968
  • N-CBZ-L-NORVALINE
  • N-CARBOBENZOXY-L-NORVALINE
  • N-ALPHA-CARBOBENZOXY-L-NORVALINE
  • N-ALPHA-CARBOBENZOXY-L-2-AMINO-PENTANOIC ACID
  • N-ALPHA-CBZ-L-NORVALINE
  • Cbz-Nva-OH
  • NALPHA-Benzyloxycarbonyl-L-norvaline
  • N-alpha-Benzyloxycarbonyl-L-norvaline, (S)-N-alpha-Z-2-amino-valeric acid
  • Z-L-Nva-OH
  • Z-L-NORVALINE extrapure
  • N-Carbobenzoxy-DL-norvaline
  • N-Cbz-DL-norvaline
  • Z-Nva-OH ,98%
  • Z-L-a-aMinovaleric acid
  • (2S)-2-{[(benzyloxy)carbonyl]aMino}pentanoic acid
  • L-Norvaline, N-[(phenylmethoxy)carbonyl]-
  • Z-L-norvaline99%
  • (2S)-2-(phenylmethoxycarbonylamino)pentanoic acid
  • 2-(phenylmethoxycarbonylamino)pentanoic acid
  • Valacyclovir Impurity 5
  • Valacyclovir Impurity 5 (N-Cbz-L-Norvaline)
  • Valacyclovir Impurity 26
  • (2S)-2-(phenylmethoxycarbonylamino)pentanoicaci
  • Z-NVA-OH USP/EP/BP
  • CBZ-L-NVA-OH
  • Diethylcarbamazine Impurity 2（Diethylcarbamazine EP Impurity B）
  • 21691-44-1
  • Peptide