ChemicalBook > CAS DataBase List > 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

Product Name
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
CAS No.
5094-14-4
Chemical Name
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
Synonyms
U 21002;13,14-dihydro-15-keto PGE1;CDUVSQMTLOYKTR-ZHALLVOQSA-N;13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1;9,15-dioxo-11α-hydroxy-prostan-1-oic acid;9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID;Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-;15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
CBNumber
CB4190392
Molecular Formula
C20H34O5
Formula Weight
354.49
MOL File
5094-14-4.mol
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13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Property

Boiling point:
537.2±35.0 °C(Predicted)
Density 
1.072±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly), THF (Slightly)
form 
Oil
pka
4.77±0.10(Predicted)
color 
Dark Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13650
Product name
13,14-dihydro-15-keto Prostaglandin E1
Purity
≥98%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
13650
Product name
13,14-dihydro-15-keto Prostaglandin E1
Purity
≥98%
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
13650
Product name
13,14-dihydro-15-keto Prostaglandin E1
Purity
≥98%
Packaging
10mg
Price
$497
Updated
2024/03/01
AK Scientific
Product number
1190AH
Product name
13,14-Dihydro-15-ketoprostaglandinE1
Packaging
10mg
Price
$650
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
59385
Product name
15-KetoProstaglandinE0
Packaging
50mg
Price
$2600
Updated
2021/12/16
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13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Chemical Properties,Usage,Production

Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.

Uses

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

Definition

ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-).

References

[1] R. KATZENSCHLAGER . Synergism between PGE1-metabolites (13,14-dihydro-prostaglandin E1, 15-keto prostaglandin E1, 15-keto-13,14-dihydro-prostaglandin E1) and nitric oxide (NO) on platelet aggregation[J]. Prostaglandins, leukotrienes, and essential fatty acids, 1992, 45 3: Pages 207-210. DOI: 10.1016/0952-3278(92)90114-x

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Preparation Products And Raw materials

Raw materials

Preparation Products

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13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Suppliers

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5094-14-4, 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1Related Search:

8-[(3S,4S)-4α-[(Z)-2-Pentenyl]-5-oxo-1-cyclopentene-3α-yl]octanoic acid 15-Hydroxy Lubiprostone 13,14-DIHYDRO-15(R)-PROSTAGLANDIN E1 11BETA-PROSTAGLANDIN E1 13,14-DIHYDROPROSTAGLANDIN E1 11-DEOXY PROSTAGLANDIN E1 15-KETO PROSTAGLANDIN E1 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1-D4 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

  • 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
  • 9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID
  • CDUVSQMTLOYKTR-ZHALLVOQSA-N
  • 13,14-dihydro-15-keto PGE1
  • 9,15-dioxo-11α-hydroxy-prostan-1-oic acid
  • U 21002
  • Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-
  • 15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
  • 5094-14-4