LEUROSINE

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Product Name: LEUROSINE
CAS No.: 23360-92-1
Chemical Name: LEUROSINE
Synonyms: amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
CBNumber: CB4205283
Molecular Formula: C46H56N4O9
Formula Weight: 808.97
MOL File: 23360-92-1.mol

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LEUROSINE Property

Melting point:: 202-205℃
Density: 1.39
pka: 11.36±0.60(Predicted)

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Safety

RIDADR: 1544
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 23360-92-1(Hazardous Substances Data)
Toxicity: dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: V314520
Product name: Vinleurosine
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

Arctom

Product number: CFN90466
Product name: Vinleurosine
Purity: ≥98%
Packaging: 10mg
Price: $833
Updated: 2021/12/16

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LEUROSINE Chemical Properties,Usage,Production

Description

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]²⁶_D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]_D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

Uses

Antineoplastic.

Uses

Vinleurosine is an antitumor compound derived from Vinca Rosea.

Definition

ChEBI: Leurosine is a vinca alkaloid.

References

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

LEUROSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LEUROSINE manufacturers

Career Henan Chemical Co

Product: LEUROSINE 23360-92-1
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

23360-92-1, LEUROSINERelated Search:

VincristineM1 4'-Deoxy Vincristine N-Desmethylvinblastine Vinorelbine EP Impurity G Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- 4-Desacetyl Vinblastine 3',4'-Anhydrovinblastine Vinorelbine EP Impurity H Cophylline desacetylnavelbine Vinorelbine EP Impurity F VINBLASTINE (2R,3R)-3-AMINO-2-HYDROXYHEXANOIC ACID LEUROSINE (R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID (R)-3-AMINO-4-(4-METHOXYPHENYL)BUTANOIC ACID (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE

4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin

4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin

amotin

LEUROSINE

Vincristine EP Impurity F

Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester

Vincristine EP Impurity F (Leurosine)

nsc-528004

Vinleurosine

4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester

(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine

(3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine

4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI

Vincristine Impurity 6(Vincristine EP Impurity F)

Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-

Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)-

4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)

methyl(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13aR)-1a-ethyl-11-(methoxycarbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate(leurosine)

Vincristine EP Impurity F(Vinorelbine EP Impurity E)

23360-92-1

C46H58N4O13S