ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
- CAS No.
- 56984-32-8
- Chemical Name
- ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
- Synonyms
- Ethyl 5-chloropyrazole-4-carboxylate;ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE;ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE;Ethyl 5-(chloromethyl)-1H-pyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-, ethyl ester
- CBNumber
- CB4206149
- Molecular Formula
- C7H9ClN2O2
- Formula Weight
- 188.61
- MOL File
- 56984-32-8.mol
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Property
- Boiling point:
- 80-82 °C(Press: 0.2 Torr)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.13±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E46318
- Product name
- Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $43
- Updated
- 2026/05/06
- Product number
- E46318
- Product name
- Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $70
- Updated
- 2026/05/06
- Product number
- E46318
- Product name
- Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $140
- Updated
- 2026/05/06
- Product number
- E46318
- Product name
- Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $280
- Updated
- 2026/05/06
- Product number
- T14103
- Product name
- ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
- Purity
- >95%
- Packaging
- 1g
- Price
- $150
- Updated
- 2026/05/24
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
31037-02-2
56984-32-8
General procedure for the synthesis of 5-chloro-4-ethoxycarbonyl-1-methylpyrazole from ethyl 5-amino-1-methylpyrazole-4-carboxylate: cuprous chloride (CuCl, 1.76 g, 1.77 mmol) was added to a solution of tert-butyl nitrite (tBuONO, 2.95 mL, 2.46 mmol) in acetonitrile (ACN), followed by the addition of 5-amino-1 -methylpyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.48 mmol). The reaction mixture was stirred at room temperature for 2 h and then heated at 60 °C for 1 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with 2N aqueous hydrochloric acid and extracted with hydrochloric acid (3×). The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated, and finally purified by fast column chromatography to afford the target product 5-chloro-4-ethoxycarbonyl-1-methylpyrazole (2.08 g, 75% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3) with chemical shifts δ: 7.90 (1H, s), 4.30 (2H, q, J = 5.4 Hz), 3.86 (3H, s), 1.34 (3H, t, J = 5.4 Hz).
References
[1] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 4, p. 326 - 339
[2] Patent: CN105164112, 2017, B. Location in patent: Paragraph 0439-0442
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US4872901, 1989, A
[5] Patent: US4620865, 1986, A
ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE manufacturers
- Product
- ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE 56984-32-8
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-30