ChemicalBook > CAS DataBase List > ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE

Product Name: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
CAS No.: 56984-32-8
Chemical Name: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE
Synonyms: Ethyl 5-chloropyrazole-4-carboxylate;ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE;ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE;Ethyl 5-(chloromethyl)-1H-pyrazole-4-carboxylate;1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-, ethyl ester
CBNumber: CB4206149
Molecular Formula: C7H9ClN2O2
Formula Weight: 188.61
MOL File: 56984-32-8.mol

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ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Property

Boiling point:: 80-82 °C(Press: 0.2 Torr)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.13±0.10(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E940158
Product name: Ethyl5-chloro-1-methyl-1H-pyrazole-4-carboxylate
Packaging: 100mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 8357AB
Product name: Ethyl5-(chloromethyl)-1H-pyrazole-4-carboxylate
Packaging: 1g
Price: $198
Updated: 2021/12/16

Oakwood

Product number: 017056
Product name: Ethyl5-Chloro-1-methyl-1H-pyrazole-4-carboxylate
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR958537
Product name: Ethyl5-chloro-1-methyl-1H-pyrazole-4-carboxylate
Purity: 95%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0320374
Product name: ETHYL 5-CHLORO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $502.16
Updated: 2021/12/16

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ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

31037-02-2

56984-32-8

General procedure for the synthesis of 5-chloro-4-ethoxycarbonyl-1-methylpyrazole from ethyl 5-amino-1-methylpyrazole-4-carboxylate: cuprous chloride (CuCl, 1.76 g, 1.77 mmol) was added to a solution of tert-butyl nitrite (tBuONO, 2.95 mL, 2.46 mmol) in acetonitrile (ACN), followed by the addition of 5-amino-1 -methylpyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.48 mmol). The reaction mixture was stirred at room temperature for 2 h and then heated at 60 °C for 1 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with 2N aqueous hydrochloric acid and extracted with hydrochloric acid (3×). The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated, and finally purified by fast column chromatography to afford the target product 5-chloro-4-ethoxycarbonyl-1-methylpyrazole (2.08 g, 75% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, CDCl3) with chemical shifts δ: 7.90 (1H, s), 4.30 (2H, q, J = 5.4 Hz), 3.86 (3H, s), 1.34 (3H, t, J = 5.4 Hz).

References

[1] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 4, p. 326 - 339
[2] Patent: CN105164112, 2017, B. Location in patent: Paragraph 0439-0442
[3] Patent: US2007/225280, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US4872901, 1989, A
[5] Patent: US4620865, 1986, A

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE Suppliers

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View Lastest Price from ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE 56984-32-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-30

56984-32-8, ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATERelated Search:

1-Methylpyrazole ETHYL 5-CHLORO-1-PHENYL PYRAZOLE-4-CARBOXYLATE RARECHEM AL BI 1001 RARECHEM AL BI 0587 3-CHLORO-5-[[(ETHOXYCARBONYL)AMINO]SULFONYL]-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, ETHYL ESTER RARECHEM AL BI 1141 RARECHEM AL BI 0329 1-METHYL-3-CHLORO-4-ETHYLFORMATE-5-PYRAZOLESULFONAMIDE RARECHEM AL BI 1140 ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE RARECHEM AL BI 0944

ETHYL 5-CHLORO-METHYL PYRAZOLE-4-CARBOXYLATE

ETHYL-5-CHLORO-1-METHYLPYRAZOLE-4-CARBOXYLATE

Ethyl 5-chloropyrazole-4-carboxylate

1H-Pyrazole-4-carboxylic acid, 5-chloro-1-methyl-, ethyl ester

Ethyl 5-(chloromethyl)-1H-pyrazole-4-carboxylate

56984-32-8