3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

Product Name: 3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
CAS No.: 227088-94-0
Chemical Name: 3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
Synonyms: AZ11645373;3-[1-[[(3'-NITRO[1;4-THIAZOLIDINEDIONE;1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione;3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-
CBNumber: CB42093152
Molecular Formula: C24H21N3O5S
Formula Weight: 463.512
MOL File: 227088-94-0.mol

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3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Property

Boiling point:: 689.1±65.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: solid
pka: 5.95±0.10(Predicted)
color: tan

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7231
Product name: AZ11645373
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $150
Updated: 2022/05/15

Tocris

Product number: 3317
Product name: AZ11645373
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

Tocris

Product number: 3317
Product name: AZ11645373
Purity: ≥98%(HPLC)
Packaging: 50
Price: $861
Updated: 2021/12/16

Usbiological

Product number: 162707
Product name: AZ 11645373
Packaging: 5mg
Price: $403
Updated: 2021/12/16

TRC

Product number: A795150
Product name: AZ11645373
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Chemical Properties,Usage,Production

Uses

A selective P2X7 receptor antagonist.

Biological Activity

Potent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively).

storage

Store at +4°C

References

1. stokes l, jiang lh, alcaraz l, et al. characterization of a selective and potent antagonist of human p2x(7) receptors, az11645373. british journal of pharmacology. 2006;149(7):880-887.

3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Suppliers

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227088-94-0, 3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedioneRelated Search:

3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

AZ11645373

1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2

3-[1-[[(3'-NITRO[1

4-THIAZOLIDINEDIONE

2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-

3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione

227088-94-0

Aromatics, Heterocycles, Neurochemicals