4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- Product Name
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- CAS No.
- 55224-94-7
- Chemical Name
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
- Synonyms
- AP-18;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal
- CBNumber
- CB42096355
- Molecular Formula
- C11H12ClNO
- Formula Weight
- 209.67
- MOL File
- 55224-94-7.mol
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- white to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A7232
- Product name
- AP-18
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- A7232
- Product name
- AP-18
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $262.2
- Updated
- 2024/03/01
- Product number
- 11912
- Product name
- AP-18
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 11912
- Product name
- AP-18
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 11912
- Product name
- AP-18
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $193
- Updated
- 2024/03/01
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties,Usage,Production
Description
AP-
Uses
AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice
Uses
AP-18 is a channel blocker that inhibits TRPA1.
Biological Activity
Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Biochem/physiol Actions
AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.
in vivo
ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception.
storage
+4°C
References
References”Citations:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Suppliers
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- Switzerland
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