POLYGODIAL

Product Name: POLYGODIAL
CAS No.: 6754-20-7
Chemical Name: POLYGODIAL
Synonyms: Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
CBNumber: CB5284348
Molecular Formula: C15H22O2
Formula Weight: 234.33
MOL File: 6754-20-7.mol

More

Less

POLYGODIAL Property

Melting point:: 57° (Barnes, Loder)
alpha: D24 -131° (c = 0.96 in ethanol)
Boiling point:: 330.7±35.0 °C(Predicted)
Density: 1.084±0.06 g/cm3(Predicted)
RTECS: QJ2850000
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
LogP: 3.522 (est)

More

Less

Safety

Risk Statements: 52/53
Safety Statements: 61
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0049
Product name: Polygodial
Purity: ≥97% (HPLC)
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0049
Product name: Polygodial
Purity: ≥97% (HPLC)
Packaging: 50mg
Price: $759
Updated: 2024/03/01

Alfa Aesar

Product number: J67380
Product name: Polygodial, 97%
Packaging: 5mg
Price: $158
Updated: 2021/12/16

Cayman Chemical

Product number: 14979
Product name: Polygodial
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14979
Product name: Polygodial
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

More

Less

POLYGODIAL Chemical Properties,Usage,Production

Description

Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2

Uses

Polygodial is a naturally occurring antifungal and antinociceptive.

Definition

ChEBI: Polygodial is an aldehyde.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

storage

Store at -20°C

References

1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590

POLYGODIAL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

POLYGODIAL Suppliers

China 25 India 3 South Korea 1 United Kingdom 5 United States 11 Global 45

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

6754-20-7, POLYGODIALRelated Search:

Minoxidil 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Nifedipine 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- (-)-FENCHONE

(-)-Tadeonal

1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-

1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-

1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-

1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde

Drim-7-ene-11,12-dial

Poligodial

(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

Polygodial (Tadeonal)

POLYGODIAL

1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-

Inhibitor,Polygodial,Antifungal,Potentiator,sesquiterpene,anti-hyperalgesic,Poligodial,inhibit,Fungal

6754-20-7

23433

Miscellaneous Natural Products