ChemicalBook > CAS DataBase List > POLYGODIAL

POLYGODIAL

Product Name: POLYGODIAL
CAS No.: 6754-20-7
Chemical Name: POLYGODIAL
Synonyms: Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;Polygodial, TRPA1 agonist;Polygodial, 10 mM in DMSO;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-
CBNumber: CB5284348
Molecular Formula: C15H22O2
Formula Weight: 234.33
MOL File: 6754-20-7.mol

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POLYGODIAL Property

Melting point:: 57° (Barnes, Loder)
alpha: D24 -131° (c = 0.96 in ethanol)
Boiling point:: 330.7±35.0 °C(Predicted)
Density: 1.084±0.06 g/cm3(Predicted)
RTECS: QJ2850000
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
LogP: 3.522 (est)

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Safety

Risk Statements: 52/53
Safety Statements: 61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0049
Product name: Polygodial
Purity: ≥97% (HPLC)
Packaging: 10mg
Price: $190
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0049
Product name: Polygodial
Purity: ≥97% (HPLC)
Packaging: 50mg
Price: $780
Updated: 2025/07/31

Cayman Chemical

Product number: 14979
Product name: Polygodial
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14979
Product name: Polygodial
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 14979
Product name: Polygodial
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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POLYGODIAL Chemical Properties,Usage,Production

Description

Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2

Uses

Polygodial is a naturally occurring antifungal and antinociceptive.

Definition

ChEBI: Polygodial is an aldehyde.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

storage

Store at -20°C

References

[1] JASMINE ESCALERA. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.[J]. The Journal of Biological Chemistry, 2008, 283 35: 24136-24144. DOI:10.1074/jbc.m710280200
[2] EUNICE ANDRE . Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats[J]. Neuropharmacology, 2004, 46 4: Pages 590-597. DOI:10.1016/j.neuropharm.2003.10.008

POLYGODIAL Preparation Products And Raw materials

Raw materials

Preparation Products

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6754-20-7, POLYGODIALRelated Search:

Minoxidil 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Nifedipine 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- (-)-FENCHONE

(-)-Tadeonal

1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-

1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-

1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-

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Drim-7-ene-11,12-dial

Poligodial

(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

Polygodial (Tadeonal)

POLYGODIAL

1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-

Inhibitor,Polygodial,Antifungal,Potentiator,sesquiterpene,anti-hyperalgesic,Poligodial,inhibit,Fungal

Polygodial, TRPA1 agonist

Polygodial, 10 mM in DMSO

6754-20-7

23433

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