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POLYGODIAL

Product Name
POLYGODIAL
CAS No.
6754-20-7
Chemical Name
POLYGODIAL
Synonyms
Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-;1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
CBNumber
CB5284348
Molecular Formula
C15H22O2
Formula Weight
234.33
MOL File
6754-20-7.mol
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POLYGODIAL Property

Melting point:
57° (Barnes, Loder)
alpha 
D24 -131° (c = 0.96 in ethanol)
Boiling point:
330.7±35.0 °C(Predicted)
Density 
1.084±0.06 g/cm3(Predicted)
RTECS 
QJ2850000
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
LogP
3.522 (est)
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Safety

Risk Statements 
52/53
Safety Statements 
61
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0049
Product name
Polygodial
Purity
≥97% (HPLC)
Packaging
10mg
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0049
Product name
Polygodial
Purity
≥97% (HPLC)
Packaging
50mg
Price
$759
Updated
2024/03/01
Alfa Aesar
Product number
J67380
Product name
Polygodial, 97%
Packaging
5mg
Price
$158
Updated
2021/12/16
Cayman Chemical
Product number
14979
Product name
Polygodial
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14979
Product name
Polygodial
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
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POLYGODIAL Chemical Properties,Usage,Production

Description

Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2

Uses

Polygodial is a naturally occurring antifungal and antinociceptive.

Definition

ChEBI: Polygodial is an aldehyde.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

storage

Store at -20°C

References

1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590

POLYGODIAL Preparation Products And Raw materials

Raw materials

Preparation Products

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POLYGODIAL Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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86-21-50328109
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3bsc@sina.com
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China
ProdList
15848
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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China
ProdList
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Sigma-Aldrich
Tel
021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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9709
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58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
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2399235533@qq.com
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China
ProdList
4933
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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11289
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Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
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sales@mitachieve.com
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China
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Aktin Chemicals, Inc.
Tel
028-85159085
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info@aktinchem.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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China
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Shanghai Moqi Biological Technology Co., LTD
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021-38218169 13341702378
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190129269@qq.com
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Shanghai Tachizaki Biomedical Research Center
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18014399201
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sales@chemlab-tachizaki.com
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guoyungurui
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Nanjing Shizhou Biology Technology Co.,Ltd
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RD International Technology Co., Limited
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Shenzhen Xinbosheng Biological Technology Co., Ltd.
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Shanghai Weiwei Biological Technology Co., Ltd.
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Beijing Taize Ruida Technology Co., Ltd.
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Shanghai Haoyang Biological Technology Co., Ltd.
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6754-20-7, POLYGODIALRelated Search:


  • (-)-Tadeonal
  • 1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (1R-(1alpha,4abeta,8aalpha))-
  • 1,2-Naphthalenedicarboxaldehyde, 1,4,4A,5,6,7,8,8A-octahydro-5,5,8A-trimethyl-, (2R,4as,8as)-
  • 1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-
  • 1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde
  • Drim-7-ene-11,12-dial
  • Poligodial
  • (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
  • Polygodial (Tadeonal)
  • POLYGODIAL
  • 1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-
  • Inhibitor,Polygodial,Antifungal,Potentiator,sesquiterpene,anti-hyperalgesic,Poligodial,inhibit,Fungal
  • 6754-20-7
  • 23433
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