[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

Product Name: [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
CAS No.: 945526-43-2
Chemical Name: [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
Synonyms: ISCK03;ISCK 03; ISCK-03;C-KIT INHIBITOR II;Stem-Cell Factor/c-Kit Inhibitor;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;T-Butylphenyl Imidazolylphenyl Sulfonamide;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03;N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
CBNumber: CB42098935
Molecular Formula: C19H21N3O2S
Formula Weight: 355.45
MOL File: 945526-43-2.mol

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Property

storage temp.: Sealed in dry,2-8°C
solubility: Soluble in ethanol or DMSO
form: solid
color: yellow
Sensitive: Light Sensitive
InChIKey: XQABBHBFHWHMKF-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I6410
Product name: ISCK03
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: I6410
Product name: ISCK03
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $440
Updated: 2024/03/01

Alfa Aesar

Product number: J65114
Product name: Stem-Cell Factor/c-Kit Inhibitor
Packaging: 10mg
Price: $139
Updated: 2023/06/20

Alfa Aesar

Product number: J65114
Product name: Stem-Cell Factor/c-Kit Inhibitor
Packaging: 50mg
Price: $459
Updated: 2021/12/16

Cayman Chemical

Product number: 15781
Product name: ISCK03
Purity: ≥95%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Chemical Properties,Usage,Production

Uses

Inhibits in vitro phosphorylation of c-Kit. Also inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells

Biological Activity

isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells.

in vitro

previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1].

in vivo

to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1].

References

[1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007).

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Suppliers

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View Lastest Price from [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- manufacturers

Career Henan Chemical Co

Product: [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- 945526-43-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

945526-43-2, [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-Related Search:

3-Chloro-2-methylpropene

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem

C-KIT INHIBITOR II

ISCK03

SteM-Cell Factor/c-Kit Inhibitor, ISCK03

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]

ISCK 03; ISCK-03

Stem-Cell Factor/c-Kit Inhibitor

inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03

T-Butylphenyl Imidazolylphenyl Sulfonamide

N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide

945526-43-2

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