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Ranolazine-d5

Product Name
Ranolazine-d5
CAS No.
1092804-87-9
Chemical Name
Ranolazine-d5
Synonyms
Ranolazine-d5;N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
CBNumber
CB42104247
Molecular Formula
C24H28D5N3O4
Formula Weight
432.56732889
MOL File
1092804-87-9.mol
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Ranolazine-d5 Property

storage temp. 
Store at -20°C
solubility 
Dichloromethane: Soluble; Methanol: Soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25424
Product name
Ranolazine-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
500μg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
25424
Product name
Ranolazine-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
1mg
Price
$434
Updated
2024/03/01
AK Scientific
Product number
2996DC
Product name
N-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
Packaging
1mg
Price
$559
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007103
Product name
RANOLAZINE-D5
Purity
95.00%
Packaging
1MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007103
Product name
RANOLAZINE-D5
Purity
95.00%
Packaging
10MG
Price
$1871.1
Updated
2021/12/16
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Ranolazine-d5 Chemical Properties,Usage,Production

Description

Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.1,2,3,4 It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).1,2 Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).2 In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.3 Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .4

Uses

Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.

References

1. Shryock, J.C., and Belardinelli, L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium Br. J. Pharmacol. 153(6),1128-1132(2008).
2. Verrier, R.L., Kumar, K., Nieminen, T., et al. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation Europace 15(3),317-324(2013).
3. Wang, W.Q., Robertson, C., Dhalla, A.K., et al. Antitorsadogenic effects of (±)-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits J. Pharmacol. Exp. Ther. 325(3),875-881(2008).
4. Tocchetti, C.G., Carpi, A., Coppola, C., et al. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction Eur. J. Heart Fail. 16(4),358-366(2014).

Ranolazine-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ranolazine-d5 Suppliers

Canada 1 China 8 United States 1 Global 10
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-025-85560043 17301488900
Fax
025-85563444
Email
info@synzest.com
Country
China
ProdList
9286
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
TLC Pharmaceutical Standards Ltd.
Tel
18012923235; 18012923235
Email
chinasales04@tlcstandards.com.cn
Country
China
ProdList
7975
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58

1092804-87-9, Ranolazine-d5Related Search:

Ranolazine

  • Ranolazine-d5
  • N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
  • 1092804-87-9
  • C24H28N3O4D5