Ranolazine-d5
- Product Name
- Ranolazine-d5
- CAS No.
- 1092804-87-9
- Chemical Name
- Ranolazine-d5
- Synonyms
- Ranolazine-d5;N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl-1,1,2,3,3-d5]-1-piperazineacetamide
- CBNumber
- CB42104247
- Molecular Formula
- C24H28D5N3O4
- Formula Weight
- 432.56732889
- MOL File
- 1092804-87-9.mol
Ranolazine-d5 Property
- storage temp.
- Store at -20°C
- solubility
- Dichloromethane: Soluble; Methanol: Soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 25424
- Product name
- Ranolazine-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 500μg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 25424
- Product name
- Ranolazine-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 1mg
- Price
- $434
- Updated
- 2024/03/01
- Product number
- 2996DC
- Product name
- N-(2,6-Dimethylphenyl)-2-[4-[1,1,2,3,3-pentadeuterio-2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
- Packaging
- 1mg
- Price
- $559
- Updated
- 2021/12/16
- Product number
- RDL0007103
- Product name
- RANOLAZINE-D5
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- RDL0007103
- Product name
- RANOLAZINE-D5
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1871.1
- Updated
- 2021/12/16
Ranolazine-d5 Chemical Properties,Usage,Production
Description
Ranolazine-d5 is intended for use as an internal standard for the quantification of ranolazine by GC- or LC-MS. Ranolazine is a piperazine derivative with cardioprotective activity.1,2,3,4 It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively).1,2 Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively).2 In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits.3 Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .4
References
1. Shryock, J.C., and Belardinelli, L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium Br. J. Pharmacol. 153(6),1128-1132(2008).
2. Verrier, R.L., Kumar, K., Nieminen, T., et al. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation Europace 15(3),317-324(2013).
3. Wang, W.Q., Robertson, C., Dhalla, A.K., et al. Antitorsadogenic effects of (±)-
4. Tocchetti, C.G., Carpi, A., Coppola, C., et al. Ranolazine protects from doxorubicin-
Ranolazine-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Ranolazine-d5 Suppliers
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- 400-9205774
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