5-Fluorobenzothiophene-2-boronic acid
- Product Name
- 5-Fluorobenzothiophene-2-boronic acid
- CAS No.
- 501944-42-9
- Chemical Name
- 5-Fluorobenzothiophene-2-boronic acid
- Synonyms
- CAS:501944-42-9;5-Fluorobenzo[b]thiene-2-boronic acid;5-Fluorobenzothiophene-2-boronic acid;5-FLUOROBENZO[B]THIEN-2-YL BORONIC ACID;5-Fluorobenzo[b]thiophene-2-boronic acid;5-fluorobenzo[b]thiophen-2-ylboronic acid;(5-fluoro-1-benzothiophen-2-yl)boronic acid;Boronic acid, (5-fluorobenzo[b]thien-2-yl)- (9CI)
- CBNumber
- CB42128690
- Molecular Formula
- C8H6BFO2S
- Formula Weight
- 196.01
- MOL File
- 501944-42-9.mol
5-Fluorobenzothiophene-2-boronic acid Property
- Boiling point:
- 393.2±45.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 6.65±0.30(Predicted)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F870063
- Product name
- 5-Fluorobenzo[b]thien-2-ylboronicAcid
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- W6555
- Product name
- 5-Fluorobenzo[b]thien-2-ylboronicacid
- Packaging
- 250mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- 090800
- Product name
- 5-Fluorobenzo[b]thien-2-ylboronic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $742
- Updated
- 2021/12/16
- Product number
- BOR0001967
- Product name
- 5-FLUOROBENZOTHIOPHENE-2-BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
- Product number
- 090800
- Product name
- 5-Fluorobenzo[b]thien-2-ylboronic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1647
- Updated
- 2021/12/16
5-Fluorobenzothiophene-2-boronic acid Chemical Properties,Usage,Production
Synthesis
70060-12-7
121-43-7
501944-42-9
General procedure for the synthesis of 5-fluorobenzothiophene-2-boronic acid from 5-fluorobenzothiophene and trimethyl borate: 5-fluorobenzothiophene (0.374 g, 2.5 mmol) was dissolved in anhydrous tetrahydrofuran (3.5 mL) in a three-necked flask under argon protection. n-Butyllithium (1.2 mL, 3 mmol) was slowly added at -78 °C to -68 °C and reacted for 25 min. Subsequently, trimethyl borate (0.33 mL, 3 mmol) was added dropwise and the reaction mixture was slowly brought to room temperature with continuous stirring for 3 hours. Upon completion of the reaction, the pH was adjusted to 6 by adding dilute hydrochloric acid and diluted with water (50 mL). Extracted with ethyl acetate (50 mL x 3), the organic phases were combined, washed once with saturated saline (50 mL) and dried over anhydrous sodium sulfate. Purified by silica gel column chromatography with dichloromethane:methanol=25:1 as eluent, a light yellow solid powder was obtained (target product 5-fluorobenzothiophene-2-boronic acid, 0.2 g, yield 38%).
References
[1] Patent: CN105294785, 2016, A. Location in patent: Paragraph 0063; 0064
5-Fluorobenzothiophene-2-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluorobenzothiophene-2-boronic acid Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10453
- Advantage
- 58
- Tel
- 0371-56787280 13137706083
- Fax
- -
- m18539565376@163.com
- Country
- China
- ProdList
- 970
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 17836913271
- Fax
- 0374-8348899
- 3224305243@qq.com
- Country
- China
- ProdList
- 2944
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60