ChemicalBook > CAS DataBase List > FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
- Product Name
- FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
- CAS No.
- 97612-24-3
- Chemical Name
- FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
- Synonyms
- Eticlopride HCl;Eticlopride hydrochl;S(-)-ETICLOPRIDE HYDROCHLORIDE (POTENT A ND SELECTIVE D2 DOPAMINE;(2S)-2-{[(3-chloro-5-ethyl-6-hydroxy-2-methoxybenzoyl)amino]methyl}-1-ethylpyrrolidinium chloride;3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamidehydrochloride;Benzamide,3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-,hydrochloride (1:1);FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
- CBNumber
- CB42130556
- Molecular Formula
- C17H26Cl2N2O3
- Formula Weight
- 377.31
- MOL File
- 97612-24-3.mol
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FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Property
- Melting point:
- 144-146 °C(Solv: acetone (67-64-1))
- storage temp.
- Desiccate at RT
- solubility
- H2O: soluble >10mg/mL
- form
- powder
- color
- off-white
- optical activity
- [α]27/D 7.2°, c = 0.3 in methanol(lit.)
- Water Solubility
- Soluble to 100 mM in water
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Safety
- WGK Germany
- 3
- RTECS
- CV2450000
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- E101
- Product name
- S-(?)-Eticlopride hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $183
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- E101
- Product name
- S-(?)-Eticlopride hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 100mg
- Price
- $489
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 29112
- Product name
- Eticlopride (hydrochloride)
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29112
- Product name
- Eticlopride (hydrochloride)
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29112
- Product name
- Eticlopride (hydrochloride)
- Packaging
- 25mg
- Price
- $252
- Updated
- 2024/03/01
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FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Chemical Properties,Usage,Production
Uses
Dopamine receptor antagonist
Uses
S-(?)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.
Biological Activity
Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic.
Biochem/physiol Actions
Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2?receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.
in vivo
Eticlopride (10 mg/kg, i.p.) hydrochloride blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing mice[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) hydrochloride alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
| Animal Model: | Sprague-Dawley rats treated with Ruinpirole (1 mg/kg) from postnatal days 1 to 21[4] |
| Dosage: | 0.01 or 0.02 mg/kg |
| Administration: | i.p. |
| Result: | Alleviated cognitive deficits produced by neonatal quinpirole treatment in both male and female rats on the place version of the MWT, as well as in males tested on the match-to-place version of the MWT (MWT tested on P22 to P28). |
IC 50
D2 Receptor: 0.09 nM (Ki)
storage
room temperature (desiccate)
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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