PROFLAVINE
- Product Name
- PROFLAVINE
- CAS No.
- 92-62-6
- Chemical Name
- PROFLAVINE
- Synonyms
- PROFLAVINE;Isoflabase;6-Diaminoacridine;3,6-Aiaminoacridine;3,6-Acridinediamine;(6-aminoacridin-3-yl)amine;Inhibitor,Proflavine,Whole,Bacterial,blood,inward,inhibit,channel,rectifier,G protein,gated
- CBNumber
- CB42131119
- Molecular Formula
- C13H11N3
- Formula Weight
- 209.25
- MOL File
- 92-62-6.mol
PROFLAVINE Property
- Melting point:
- 281° (Schpff); mp 288° (Albert)
- Boiling point:
- 338.61°C (rough estimate)
- Density
- 1.1847 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- DMSO: 23 mg/mL (109.92 mM);Ethanol: 2 mg/mL (9.56 mM)
- form
- powder to crystal
- pka
- 9.65(at 20℃)
- color
- Light yellow to Brown
- EPA Substance Registry System
- 3,6-Acridinediamine (92-62-6)
Safety
- HS Code
- 2933.99.4600
- Hazardous Substances Data
- 92-62-6(Hazardous Substances Data)
- Toxicity
- LD50 s.c. in mice: 0.14 g/kg (Rubbo)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PH006894
- Product name
- 3,6-acridinediamine
- Purity
- AldrichCPR
- Packaging
- 25mg
- Price
- $172
- Updated
- 2023/06/20
- Product number
- A3219
- Product name
- Acridine-3,6-diamine
- Packaging
- 1G
- Price
- $123
- Updated
- 2024/03/01
- Product number
- A3219
- Product name
- Acridine-3,6-diamine
- Packaging
- 5G
- Price
- $368
- Updated
- 2024/03/01
- Product number
- 42558
- Product name
- Acridine-3,6-diamine,≥96%(HPLC)
- Purity
- ≥96%(HPLC)
- Packaging
- 1G
- Price
- $112.09
- Updated
- 2021/12/16
- Product number
- 156639
- Product name
- Acridine-3,6-diamine
- Packaging
- 0.500g
- Price
- $240
- Updated
- 2021/12/16
PROFLAVINE Chemical Properties,Usage,Production
Definition
ChEBI: An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of bur s and infected wounds.
Safety Profile
Poison by intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also other diaminoacridine entries.
Enzyme inhibitor
This dye (FWfree-base = 209.25 g/mol; CAS 92-62-6; orange-red solid; M.P. = 281 or 288°C; soluble in water; pKa = 9.65; solutions are light sensitive; insoluble in organic solvents such as benzene, diethyl ether, and chloroform), also known as proflavin and 3,6-acridinediamine, is a mutagen that intercalates in double-stranded DNA, inhibiting both DNA and RNA biosynthesis. Proflavine can also participate in the photooxidation of proteins (e.g., dopa decarboxylase. In addition, proflavine can inhibit a number of enzymes directly. For xample scriflavine, a mixture of proflavine with 3,6-diamino-10-methylacridinium chloride, inhibits protein kinase C. Target(s): L-amino-acid oxidase; carbonic anhydrase, or carbonate dehydratase, Ki ≈ 10 mM; chymotrypsin; DNA (cytosine-5-)-methyltransferase; DNA-directed RNA polymerase; dopa decarboxylase; F1Fo ATPase, or F1Fo ATP synthase, or H+-transporting two-sector ATPase; ficain, or ficin; glutamate decarboxylase; lysozyme; monoamine oxidase; NADH:cytochrome b5 reductase; nucleoside-triphosphatase, nuclear-envelope; papain; poly(ADP-ribose) glycohydrolase; polynucleotide adenylyltransferase, or poly(A) polymerase; pyruvate kinase; RNA-directed DNA polymerase; thrombin; tRNA adenylytltransferase; tRNA (guanine-N2-)-methyltransferase; tRNA cytidylyltransferase; tRNA methyltransferases; tRNA nucleotidyltransferase; and trypsin.
Purification Methods
Proclavine (3,6-diaminoacridine) [92-62-6] M 209.2, m 284-286o, pK 1 -2.7, pK 2 0 . 5 5 , pK 3 9.49. It crystallises from aqueous MeOH. The picrate crystallises from aqueous pyridine with m ~185o. [Beilstein 22 H 487, 22 I 649, 22 II 397, 22 III/IV 5487, 22/11 V 322.] For proflavin see 3,6-diaminoacridine hydrochloride.
PROFLAVINE Preparation Products And Raw materials
Raw materials
Preparation Products
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