4-PHENYL-1,2,3-THIADIAZOLE

Product Name: 4-PHENYL-1,2,3-THIADIAZOLE
CAS No.: 25445-77-6
Chemical Name: 4-PHENYL-1,2,3-THIADIAZOLE
Synonyms: BUTTPARK 91\16-70;4-phenylthiadiazole;4-PHENYL-1,2,3-THIADIAZOLE;1,2,3-Thiadiazole, 4-phenyl-;4-Phenyl-1,2,3-thiadiazole ,98%
CBNumber: CB4213954
Molecular Formula: C8H6N2S
Formula Weight: 162.21
MOL File: 25445-77-6.mol

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4-PHENYL-1,2,3-THIADIAZOLE Property

Melting point:: 78°C
Boiling point:: 100°C 1,5mm
Density: 1.241±0.06 g/cm3(Predicted)
Flash point:: 100°C/1.5mm
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: -4.23±0.22(Predicted)
BRN: 119480

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
HazardClass: IRRITANT
HS Code: 29420000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S541524
Product name: 4-PHENYL-1,2,3-THIADIAZOLE
Purity: Aldrich
Packaging: 250mg
Price: $29.8
Updated: 2024/03/01

Alfa Aesar

Product number: L20197
Product name: 4-Phenyl-1,2,3-thiadiazole
Packaging: 1g
Price: $109
Updated: 2021/12/16

Alfa Aesar

Product number: L20197
Product name: 4-Phenyl-1,2,3-thiadiazole
Packaging: 5g
Price: $416
Updated: 2021/12/16

Alfa Aesar

Product number: L20197
Product name: 4-Phenyl-1,2,3-thiadiazole
Packaging: 250mg
Price: $43.2
Updated: 2021/12/16

Cayman Chemical

Product number: 10011055
Product name: 4-phenyl-1,2,3-Thiadiazole
Packaging: 100mg
Price: $31
Updated: 2023/06/20

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4-PHENYL-1,2,3-THIADIAZOLE Chemical Properties,Usage,Production

Description

Cytochrome P450 (CYP450) enzymes are a superfamily of oxidative catalysts important in the biosynthesis and metabolism of a wide range of endogenous molecules as well as the metabolism of xenobiotics. For example, CYP2B4 metabolizes substituted amines, CYP2E1 metabolizes various alcohols and halogenated alkenes, and CYP1A2 catalyzes the oxygenation of aromatic compounds and polycyclic hydrocarbons. 4-phenyl-1,2,3-Thiadiazole is, at 100 μM, a selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1), but not others (CYP1A2), with inactivation occurring in a mechanism-based manner. 1,2,3-Thiadiazole compounds and their derivatives, including 4-phenyl-1,2,3-thiadiazole, are also commonly used as fungicides, herbicides, and plant growth regulators.

Chemical Properties

Off-white to light brown solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 28, p. 442, 1985 DOI: 10.1021/jm00382a009

4-PHENYL-1,2,3-THIADIAZOLE Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Hydrazinium hydroxide solution Sodium chloride Acetophenone Tosyl chloride Tetrahydrofuran Diethyl ether Methanol Thionyl chloride PETROLEUM ETHER

Preparation Products

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4-PHENYL-1,2,3-THIADIAZOLE Suppliers

Belgium 1 China 23 France 1 Germany 1 India 2 Japan 1 United Kingdom 2 United States 7 Global 38

J & K SCIENTIFIC LTD.

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25445-77-6, 4-PHENYL-1,2,3-THIADIAZOLERelated Search:

4-PHENYL-1,2,3-THIADIAZOL-5-AMINE 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOHYDRAZIDE 4-(4-NITROPHENYL)-1,2,3-THIADIAZOLE 4-(1,2,3-THIADIAZOL-4-YL)PHENOL 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE 4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE 5-CHLORO-4-PHENYL-1,2,3-THIADIAZOLE 4-(1,2,3-THIADIAZOL-4-YL)BENZOIC ACID 4-(4-BROMOPHENYL)-1,2,3-THIADIAZOLE 4-(1,2,3-THIADIAZOL-4-YL)BENZONITRILE 4-(1,2,3-THIADIAZOL-4-YL)ANILINE 4-PHENYL-1,2,3-THIADIAZOLE 4,5-DIPHENYL-1,2,3-THIADIAZOLE 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID 2-AMINO-5-(4-FLUOROPHENYL)-1 3 4-THIADI& 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE

4-PHENYL-1,2,3-THIADIAZOLE

BUTTPARK 91\16-70

4-Phenyl-1,2,3-thiadiazole ,98%

4-phenylthiadiazole

1,2,3-Thiadiazole, 4-phenyl-

25445-77-6