ChemicalBook > CAS DataBase List > 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE

Product Name
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
CAS No.
64273-28-5
Chemical Name
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
Synonyms
5-methyl-4-phenylthiadiazole;5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE;1,2,3-Thiadiazole, 5-methyl-4-phenyl-
CBNumber
CB9294824
Molecular Formula
C9H8N2S
Formula Weight
176.24
MOL File
64273-28-5.mol
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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO
form 
solid
color 
Red-brown
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Hazard Note 
Harmful
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
T344123
Product name
4-Phenyl-5-methyl-1,2,3-Thiadiazole
Packaging
500mg
Price
$70
Updated
2021/12/16
Apolloscientific
Product number
OR26197
Product name
5-Methyl-4-phenyl-1,2,3-thiadiazole
Purity
95%
Packaging
1g
Price
$86
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-1-V0
Product name
5-Methyl-4-phenyl-1,2,3-thiadiazole
Purity
95%
Packaging
1g
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
084918
Product name
5-Methyl-4-phenyl-1,2,3-thiadiazole
Purity
97%
Packaging
1g
Price
$102
Updated
2021/12/16
AK Scientific
Product number
V7087
Product name
5-Methyl-4-phenyl-1,2,3-thiadiazole
Packaging
1g
Price
$104
Updated
2021/12/16
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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Chemical Properties,Usage,Production

Uses

4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1.

Biological Activity

4-phenyl-5-methyl-1,2,3-thiadiazole is a cyp2b4 and cyp2e1 inhibitor.cytochrome p450 (cyp450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. cyp2b4 can metabolize substituted amines, while cyp2e1 metabolizes various alcohols and halogenated alkenes.

in vitro

4-phenyl-5-methyl-1,2,3-thiadiazole (pmt) was found to be slightly more inhibitory to p450s 2e1 and 1a2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (dpt). by contrast, 4-phenyl-5-hydrogen-1,2,3-thiadiazole (pt), a weaker inhibitor than dpt and pmt with p450s 2e1 and 2b4, was comparable to pmt and more effective than dpt with p450 1a2. moreover, pmt, dpt, as well as pt showed no inactivation of either p450 2e1 or 2b4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the p450 system. furthremore, the lack of inactivation of the p450 isoforms by pmt, dpt, and pt suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. in additioin, the 1,2,3-thiadiazole ring could be oxidized by the p450 system [1].

References

[1] babu, b. r. and vaz, a.d.n. 1,2,3-thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome p450 inhibitors. biochemistry 36, 7209-7216 (1997).

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Suppliers

Belgium 1 China 8 Germany 1 India 2 United Kingdom 2 United States 9 Global 23
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
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China
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Beijing FYF Chemicals Co., Ltd
Tel
010-57903446 15869909019
Fax
010-57903446
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168931144@qq.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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Energy Chemical
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Shanghai Haohong Scientific Co., Ltd.
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ApexBio Technology
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United States
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64273-28-5, 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLERelated Search:

4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOHYDRAZIDE 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE 4,5-DIPHENYL-1,2,3-THIADIAZOLE (4-PHENYL-1,2,3-THIADIAZOL-5-YL)METHANOL 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID 3-METHYL-5-PHENYL-1,2,4-THIADIAZOLE 4-PHENYL-1,2,3-THIADIAZOLE 5-Cyanimino-4,5-dihydro-4-methyl-3-phenyl-1,2,4-thiadiazole ETHYL 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE MORPHOLINO(4-PHENYL-1,2,3-THIADIAZOL-5-YL)METHANONE N-(4-BROMOPHENYL)-4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE N-ALLYL-4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE 4-PHENYL-N-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOLE-5-CARBOXAMIDE N,N-DIMETHYL-4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE N-METHYL-4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE [4-(2-FLUOROPHENYL)PIPERAZINO](4-PHENYL-1,2,3-THIADIAZOL-5-YL)METHANONE N-(2,3-DICHLOROPHENYL)-4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXAMIDE (2,6-DIMETHYLMORPHOLINO)(4-PHENYL-1,2,3-THIADIAZOL-5-YL)METHANONE

  • 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
  • 5-methyl-4-phenylthiadiazole
  • 1,2,3-Thiadiazole, 5-methyl-4-phenyl-
  • 64273-28-5
  • C9H8N2S