5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
- Product Name
- 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
- CAS No.
- 64273-28-5
- Chemical Name
- 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE
- Synonyms
- 5-methyl-4-phenylthiadiazole;5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE;1,2,3-Thiadiazole, 5-methyl-4-phenyl-
- CBNumber
- CB9294824
- Molecular Formula
- C9H8N2S
- Formula Weight
- 176.24
- MOL File
- 64273-28-5.mol
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO
- form
- solid
- color
- Red-brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T344123
- Product name
- 4-Phenyl-5-methyl-1,2,3-Thiadiazole
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- OR26197
- Product name
- 5-Methyl-4-phenyl-1,2,3-thiadiazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 7H70-1-V0
- Product name
- 5-Methyl-4-phenyl-1,2,3-thiadiazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 084918
- Product name
- 5-Methyl-4-phenyl-1,2,3-thiadiazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- V7087
- Product name
- 5-Methyl-4-phenyl-1,2,3-thiadiazole
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Chemical Properties,Usage,Production
Uses
4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1.
Biological Activity
4-phenyl-5-methyl-1,2,3-thiadiazole is a cyp2b4 and cyp2e1 inhibitor.cytochrome p450 (cyp450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. cyp2b4 can metabolize substituted amines, while cyp2e1 metabolizes various alcohols and halogenated alkenes.
in vitro
4-phenyl-5-methyl-1,2,3-thiadiazole (pmt) was found to be slightly more inhibitory to p450s 2e1 and 1a2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (dpt). by contrast, 4-phenyl-5-hydrogen-1,2,3-thiadiazole (pt), a weaker inhibitor than dpt and pmt with p450s 2e1 and 2b4, was comparable to pmt and more effective than dpt with p450 1a2. moreover, pmt, dpt, as well as pt showed no inactivation of either p450 2e1 or 2b4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the p450 system. furthremore, the lack of inactivation of the p450 isoforms by pmt, dpt, and pt suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. in additioin, the 1,2,3-thiadiazole ring could be oxidized by the p450 system [1].
References
[1] babu, b. r. and vaz, a.d.n. 1,2,3-thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome p450 inhibitors. biochemistry 36, 7209-7216 (1997).
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Suppliers
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