1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA

Product Name: 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
CAS No.: 14901-16-7
Chemical Name: 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
Synonyms: U-14624;phenylthiazolylthiourea;n-phenyl-n’-2-thiazolyl-thioure;1-Phenyl-3-(2-thiazolyl)thiourea;1-PHENYL-3-(THIAZOL-2-YL)THIOUREA;N-Phenyl-N'-(2-thiazolyl)thiourea;N-Phenyl-N'-(thiazol-2-yl)thiourea;Thiourea, N-phenyl-N'-2-thiazolyl-;1-phenyl-3-(2-thiazole)-2-thiourea;1-phenyl-3-(2-thiazolyl)-2-thio-ure
CBNumber: CB4215064
Molecular Formula: C10H9N3S2
Formula Weight: 235.33
MOL File: 14901-16-7.mol

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1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Property

Melting point:: 183-185 °C (dec.)(lit.)
Density: 1.3479 (rough estimate)
refractive index: 1.5500 (estimate)
form: Solid
color: Off-white to yellow
CAS DataBase Reference: 14901-16-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
WGK Germany: 3
RTECS: YU1398000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0006993
Product name: 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
Purity: 95.00%
Packaging: 5MG
Price: $503.56
Updated: 2021/12/16

aablocks

Product number: AA007J8J
Product name: 1-Phenyl-3-(thiazol-2-yl)thiourea
Purity: >90%
Packaging: 1mg
Price: $152
Updated: 2021/12/16

aablocks

Product number: AA007J8J
Product name: 1-Phenyl-3-(thiazol-2-yl)thiourea
Purity: >90%
Packaging: 5mg
Price: $163
Updated: 2021/12/16

aablocks

Product number: AA007J8J
Product name: 1-Phenyl-3-(thiazol-2-yl)thiourea
Purity: >90%
Packaging: 10mg
Price: $187
Updated: 2021/12/16

aablocks

Product number: AA007J8J
Product name: 1-Phenyl-3-(thiazol-2-yl)thiourea
Purity: >90%
Packaging: 20mg
Price: $230
Updated: 2021/12/16

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1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Chemical Properties,Usage,Production

Chemical Properties

light brown fine crystalline powder

Uses

U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].

in vivo

U-14624 (50 mg/kg; i.p.; daily for 5-7 days) suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes in rats^[2].

Animal Model:	150-260 g, Male Sprague-Dawley rats^[2]
Dosage:	25 mg/kg
Administration:	I.p.; daily for 3 days
Result:	Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer.

Animal Model:	150-260 g, Male Sprague-Dawley rats^[2]
Dosage:	50 mg/kg
Administration:	I.p.; daily for 5-7 days
Result:	Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes.

References

[1] Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. DOI:10.3181/00379727-133-34571
[2] Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. DOI:10.1016/0006-2952(80)90345-7

1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Suppliers

China 25 France 1 Germany 2 Japan 1 Switzerland 1 United Kingdom 4 United States 10 Global 44

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14901-16-7, 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREARelated Search:

1-Methyl-3-phenyl-2-thiourea 1-PHENYL-2-THIOUREA Thiazole 2-Aminothiazole N,N'-DIMETHYLTHIOUREA BUTTPARK 16\06-67 N-METHYLTHIOUREA 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA

1-PHENYL-3-(THIAZOL-2-YL)THIOUREA

1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA

:1-phenyl-3-(1,3-thiazol-2-yl)thiourea

1-phenyl-3-(2-thiazolyl)-2-thio-ure

n-phenyl-n’-2-thiazolyl-thioure

phenylthiazolylthiourea

Urea, 1-phenyl-3-(2-thiazolyl)-2-thio.

1-Phenyl-3-(2-thiazolyl)thiourea

N-Phenyl-N'-(2-thiazolyl)thiourea

N-Phenyl-N'-(thiazol-2-yl)thiourea

U-14624

1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA 97&

Thiourea, N-phenyl-N'-2-thiazolyl-

1-phenyl-3-(2-thiazole)-2-thiourea

N-phenyl-N'-(1,3-thiazol-2-yl)thiourea

14901-16-7

C10H9N3S2

Dopamine beta-hydroxylase inhibitor.

Biochemicals and Reagents

BioChemical

D to K

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates