(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

Product Name: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
CAS No.: 156311-83-0
Chemical Name: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
Synonyms: PYAOP;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V);PyAOP Novabiochem;(7-Azabenzotriazol-1;PVP-VACOPOLYMERSERIES;(7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDI;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophospho;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphoni;3H-1,2,3-triazolo[4,5-b]pyridine phosphonium derivative;tripyrrolidin-1-yl(triazolo4,5-b]pyridin-3-yloxy)phosphanium
CBNumber: CB4221362
Molecular Formula: C17H27F6N7OP2
Formula Weight: 521.39
MOL File: 156311-83-0.mol

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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Property

Melting point:: 163-168 °C(lit.)
RTECS: TH3890000
storage temp.: -20°C
solubility: Soluble in water or 1% acetic acid
form: Powder or Crystalline Powder
color: White to off-white
Water Solubility: Soluble in water.
Major Application: peptide synthesis
InChI: InChI=1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
InChIKey: CBZAHNDHLWAZQC-UHFFFAOYSA-N
SMILES: [P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)ON1N=NC2C=CC=NC1=2
CAS DataBase Reference: 156311-83-0(CAS DataBase Reference)
EPA Substance Registry System: Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) (156311-83-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51221
Product name: PyAOP
Purity: Novabiochem?
Packaging: 25g
Price: $201
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51221
Product name: PyAOP
Purity: Novabiochem?
Packaging: 100g
Price: $602
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51221
Product name: PyAOP
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $4720
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.51221
Product name: PyAOP
Purity: Novabiochem<SUP>®</SUP>
Packaging: 1 kg
Price: $4720
Updated: 2025/07/31

Sigma-Aldrich

Product number: 535303
Product name: (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Purity: 96%
Packaging: 1g
Price: $121
Updated: 2025/07/31

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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties,Usage,Production

Chemical Properties

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder

Uses

PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).

Uses

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

reaction suitability

reaction type: Coupling Reactions

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Suppliers

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Suzhou Highfine Biotech Co., Ltd

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View Lastest Price from (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate 156311-83-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Anhuyan (Hainan) Biotechnology Co., LTD

Product: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate 156311-83-0
Price: US $0.00/G/KG
Min. Order: 1G/KG
Purity: 99%
Supply Ability: 100000
Release date: 2025-02-12

PNP Biotech Co. Ltd

Product: PyAOP 156311-83-0
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-09-16

156311-83-0, (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphateRelated Search:

Polyvinylpyrrolidone 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate CHLOROPHOSPHONAZO III N-Methyl-2-pyrrolidone Lithium hexafluorophosphate METHYL-2-PYRROLIDONE TRIS(DIETHYLAMINO)PHOSPHINE 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate HOAt Hexafluorophosphoric acid PVP-VACOPOLYMERSERIES 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphonium hexafluorophosphate(PyAOP)

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V)

PyAOP (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphoniuM hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate

tris(pyrrolidin-1-yl)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})phosphanium

(7Azabenzotriazol1yloxy)tripyrrolidinophosphonium hexafluophosphate

(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluoropho sphate, 99+% white crystalline powder

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexa

tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphonium

tris(1-pyrrolidinyl)-(3-triazolo[4,5-b]pyridinyloxy)phosphonium hexafluorophosphate

(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate 96%

PYAOP

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphat

7-Azabenzotriazol-1-yloxy)tripyrrolidino-phosphonium hexafluorophosphate≥ 99% (HPLC)

PyAOP Novabiochem

(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate

(7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE

7-AZABENZOTRIAZOL-1-YLOXY-TRIS-(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE

(7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

(7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDI

(7-Azabenzotriazol-1-yloxy)tripyrrolidinophospho

PY (7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE

PYAOP ((7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE)

3H-1,2,3-triazolo[4,5-b]pyridine phosphonium derivative

(7-Azabenzotriazol-1

(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphoni

PVP-VACOPOLYMERSERIES

(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphoniuM hexafluorophosphate, 99+%

Phosphorus(1+), [3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)

Tripyrrolidin-1-yl(triazolo4,5-bpyridin-3-yloxy)phosphonium hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate USP/EP/BP

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrol...

tripyrrolidin-1-yl(triazolo4,5-b]pyridin-3-yloxy)phosphanium

(T-4)-[3-(hydroxy-κO)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-) (1:1)

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphoniumhex

(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, PyAOP

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate，98%

(T-4)-[3-(Hydroxy-kappao)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-pyrrolidin-1-yl-phosphorus(I) hexafluorophosphate(I)

156311-83-0

C17H27N7OPPF6

C17H27F6N7OP2

Coupling

Synthetic Reagents

Phosphonium/Uronium/Formamidinium

Coupling Reagent